Filtry
Flt3 ligand synergizes with granulocyte-colony-stimulating factor in bone marrow mobilization to improve functional outcome after spinal cord injury in the rat
) and/or the cytokine fms-like thyrosin kinase 3 (Flt3) ligand on functional outcome and tissue a balloon-induced compression lesion were injected with G-CSF and/or Flt3 ligand by G-CSF, Flt3 ligand
EA - Morfologické obory a cytologie
- 2011 •
- Jx •
- Odkaz
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
Pilot study of Flt3 Ligand comparing intraperitoneal with subcutaneous routes on hematologic and immunologic responses in patients with peritoneal carcinomatosis and mesotheliomas
This study compared the clinical toxicity and hematological effects of i.p. and s.c. administration of fmslike tyroisne kinase-3-ligand, a truncated glycoprotein that increases dendritic cells and monocytes....
FD - Onkologie a hematologie
- 2003 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Theoretical Studies Aimed at Finding FLT3 Inhibitors and a Promising Compound and Molecular Pattern with Dual Aurora B/FLT3 Activity
FLT3 and dual Aurora B/FLT3 inhibitors have shown relevance in the search was designed to investigate the interactions between human FLT3 in the kinase domain, achieved an R-2 of 0.82, suggesting that the binding conformati...
Biochemistry and molecular biology
- 2020 •
- Jimp •
- Odkaz
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
13q12.2 deletions in acute lymphoblastic leukemia lead to upregulation of FLT3 through enhancer hijacking
Mutations in the FMS-like tyrosine kinase 3 (FLT3) gene in 13q12.2 are among deletions occur immediately 5' of FLT3 and involve the PAN3 locus. By detailed of a topologically associating domain border and an enhancer of FLT...
Oncology
- 2020 •
- Jimp •
- Odkaz
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
High levels of FLT3-ligand in bone marrow and peripheral blood of patients with advanced multiple myeloma
: Bone marrow- and peripheral blood plasma levels of FLT3-L, soluble TIE2, endostatin: Median FLT3-L expression increased from MGUS (58.77 pg/ml in bone marrow; 80.40 pg in peripheral blood; NDMM vs. RRMM p<0.001). A cut-off valu...
Hematology
- 2017 •
- Jimp •
- Odkaz
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
The expression of the soluble isoform of hFlt3 ligand by recombinant vaccinia virus enhances immunogenicity of the vector
Coexpression of Flt3L by replication-competent virus P13-FL-SigE7LAMP induced enhancement of the cellular immune response against HPV16 E7 and VACV E3 proteins as well as increased anti-tumor efficacy in both the protective and therapeutic immunizati...
FD - Onkologie a hematologie
- 2009 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Attenuation of vaccinia virus by the expression of human Flt3 ligand
The expression of Flt3 ligand (FL) by recombinant vaccinia virus (rVACV) highly influenced properties of the virus in dependence on the level of expression. High production of FL driven by the strong synthetic promoter decreased the...
CE - Biochemie
- 2010 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Current knowledge about FLT3 gene mutations, exploring the isoforms, and protein importance in AML
mutations in the FLT3 gene, which plays a critical role in haematopoiesis and haematopoietic homeostasis. This review explores the current understanding of FLT3 gene mutations and isoforms and the importance of the FLT3 pr...
Hematology
- 2024 •
- Jimp •
- Odkaz
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Flt3 ligand expands CD4+FoxP3+regulatory T cells in human subjects
CD4+CD25+FoxP3+ naturally occurring regulatory T (Treg) cells play a crucial role in the maintenance of immune tolerance and in preventing autoimmune pathology. Interventions that expand Treg cells are highly desirable, as they may offer novel treatm...
EC - Imunologie
- 2013 •
- Jx •
- Odkaz
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
Inhibition of FLT3-ITD Kinase in Acute Myeloid Leukemia by New Imidazo[1,2-b]pyridazine Derivatives Identified by Scaffold Hopping
FLT3 kinase is a potential drug target in acute myeloid leukemia (AML). Patients with FLT3 mutations typically have higher relapserates and worse outcomes than patients without FLT3 mutations. In this study, we investigated...
Oncology
- 2023 •
- Jimp •
- Odkaz
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
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