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Filtry

12 188 (0,088s)

Výsledek výzkumu

Generation of Remosomes by the SWI/SNF Chromatin Remodeler Family

Chromatin remodelers are complexes able to both alter histone-DNA interactions and to mobilize nucleosomes. The mechanism of their action and the conformation of remodeled of the products of nucleosome remodeling by SWI/SNF...

Biological sciences

  • 2019
  • Jimp
  • Odkaz
Výsledek výzkumu

Myeloperoxidase Mediates Postischemic Arrhythmogenic Ventricular Remodeling

Rationale: Ventricular arrhythmias remain the leading cause of death in patients suffering myocardial ischemia. Myeloperoxidase, a heme enzyme released by polymorphonuclear neutrophils, accumulates within ischemic myocardium and has been lin...

Cardiac and Cardiovascular systems

  • 2017
  • Jimp
  • Odkaz
Výsledek výzkumu

Effects of Trandolapril on Structural, Contractile and Electrophysiological Remodeling in Experimental Volume Overload Heart Failure

Chronic volume overload induces multiple cardiac remodeling processes hypothesized that chronic angiotensin-converting enzyme (ACE) inhibition by trandolapril might affect various remodeling processes differentially, thus a...

Cardiac and Cardiovascular systems

  • 2021
  • Jimp
  • Odkaz
Výsledek výzkumu

Lung Mast Cells and Hypoxic Pulmonary Hypertension

by the increase of pulmonary vascular tone and the structural remodeling of peripheral and they are alsoinvolved in tissue remodeling. Tissue hypoxia is associated with mast cell activation and the release of proteolytic enzyme...

ED - Fyziologie

  • 2012
  • Jx
  • Odkaz
Výsledek výzkumu

Mechanisms of chromatin remodeling

are associated with chromatin remodeling increasing DNA accessibility to DNA-binding proteins-dependent chromatin remodeling complexes which work as machines to physically dissociatethe DNA from histones and complex enzyme...

EB - Genetika a molekulární biologie

  • 2001
  • Jx
Výsledek výzkumu

Remosomes: RSC generated non-mobilized particles with approximately 180 bp DNA loosely associated with the histone octamer

Intermediate products generated during the process of chromatin remodeling-electron microscopy and molecular biology methods. This remosome (remodeled nucleosome) is a metastable product of the first phase of the remodeling...

CE - Biochemie

  • 2010
  • Jx
Výsledek výzkumu

Immunohistochemical expression of matrix metalloproteinases in the rabbit corneal epithelium upon UVA and UVB irradiation

Matrix metalloproteinases (MMPs) are proteolytic enzymes involved in tissue remodeling and wound healing. These enzymes degrade and also synthesize components of the extracellular matrix. Overexpression of MMPs results in e...

FF - ORL, oftalmologie, stomatologie

  • 2012
  • Jx
  • Odkaz
Výsledek výzkumu

ACTIVE 1 and upstream therapy

Atrial fibrillation is the most common sustained arrhythmia. It is associated with increased morbidity and mortality and decreased quality of life. Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers reduce morbidity a...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2009
  • Jx
Výsledek výzkumu

Possibilities of influencing the myocardial remodelin;

Current possibilities of chronic heart failure treatment with positive impact on patient prognosis interfere with the pathophysiological processes of myocardial remodeling. RAAS-inhibitors and beta-blockers are considered to be effective pha...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2013
  • Jx
  • Odkaz
Výsledek výzkumu

ACE inhibitors, sartans and atrial fibrillation

Atrial fibrillation is the most common susteined arrhythmia. It is associated with increased morbidity and mortality and decreased duality of life. There is a question, if RAAS blockers should be given for lone AF without proved organic heart damane,...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2009
  • Jx
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