Filtry
Selective inhibitors for JNK signalling: a potential targeted therapy in cancer
. Currently, designing effective and specific JNK inhibitors is an active area in the cancer treatment. Some ATP-competitive inhibitors of JNK, such as SP600125 in cancer. Some selective inhibitors of ...
Medicinal chemistry
- 2020 •
- Jimp •
- Odkaz
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
Jun N-terminal kinase as a potential molecular target for prevention and treatment of dermal fibrosis
These data identify JNK as a MAPK important for the activation of fibroblasts and for the synthesis of extracellular matrix in fibroblasts of SSc patients. The selective JNK-inhibitor CC930 disclosed potent anti-fibrotic ef...
FE - Ostatní obory vnitřního lékařství
- 2012 •
- Jx •
- Odkaz
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
Pharmacological inhibitors of JNK and ERK kinases SP600125 and U0126 are not appropriate tools for studies of drug metabolism because they activate aryl hydrocarbon receptor.
Mitogen-activated protein kinases (MAPKs) are important regulators of aryl hydrocarbon receptor (AhR). An immense progress in MAPKs' biochemistry was attained with the discovery of their specific pharmacological inhibitors. Unfortunately, th...
CE - Biochemie
- 2008 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Using the MAP kinase JNK to prepare the culture medium for prolongation of vitality of mammalian oocytes in vitro
Solving have to do with using inhibitor maps kinase JNK for preparation cultural media on extension service life mammalians oocyt in vitro, when take away inhibitormaps kinase JNK. Storage take away mammalians oocyt in cond...
EB - Genetika a molekulární biologie
- 2006 •
- P •
- Odkaz
Rok uplatnění
P - Patent
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SB203580, a pharmacological inhibitor of p38 MAP kinase transduction pathway activates ERK and JNK MAP kinases in primary cultures of human hepatocytes.
. In the current paper, we studied the effect of SB203580, a pharmacological inhibitor of p38-terminal kinase (JNK) pathways both in primary human hepatocytes and tumor cell lines activates ERK and JNK in primary cultures o...
CE - Biochemie
- 2008 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Inhibition of c-Jun N-terminal kinase (JNK) suppresses porcine oocyte aging in vitro
in vitro matured oocytes for another 1 to 4 days in the presence of a JNK inhibitor. The inhibition of JNK significantly protected oocytes from the fragmentation (0.0. The key factor in apoptotic pathway regulation is c-Ju...
GI - Šlechtění a plemenářství hospodářských zvířat
- 2013 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Inhibition of c-Jun N-terminal kinase (JNK) suppresses porcine oocyte ageing in vitro
days in the presence of a JNK inhibitor. The inhibition of JNK significantly protected the oocytes from fragmentation (0% of fragmented oocytes under JNK inhibition. The key factor in apoptotic pathway regulation ...
EB - Genetika a molekulární biologie
- 2013 •
- Jx •
- Odkaz
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
Výsledek na webu
Resveratrol Enhances NK Cell Cytotoxicity: Possible Role for Aryl Hydrocarbon Receptor
We speculate here that the effects of resveratrol and JNK inhibitor SP600125 observed by Lu and Chen could be also mediated by aryl hydrocarbon receptor (AhR)....
FR - Farmakologie a lékárnická chemie
- 2010 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
THE CELL SURVIVAL FUNCTION OF JNK
c-Jun N-terminal kinases (JNK) can be activated by multiple environmental stress, leading to varied and contradictory cellular response. JNK mediates cell discussed the mechanism of JNK cell survival function and the distin...
KA - Vojenství
- 2014 •
- Jx
Rok uplatnění
Jx - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
JNK signaling in cancer cell survival
c-Jun N-terminal kinase (JNK) is involved in cancer cell apoptosis; however. JNK acts synergistically with NF-kappa B, JAK/STAT, and other signaling molecules to exert a survival function. JNK positively regulates autophagy...
Pharmacology and pharmacy
- 2019 •
- Jimp •
- Odkaz
Rok uplatnění
Jimp - Článek v periodiku v databázi Web of Science
Výsledek na webu
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