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Projekt

Is the main inhibitory system damaged in progressive epileptogenesis after pilocarpine-induced seizures in adult and immature rats? (GA309/97/0552)

Gamma-aminobutyric acid is the main inhibitory transmitter in the brain. Insuffiency of this inhibitory system represents an important factor in epileptogenesis. The role of this system and especially the synthesis of GABA will be s...

FH - Neurologie, neurochirurgie, neurovědy

  • 1997 - 1999
    • •
  • 4 981 tis. Kč
    • •
  • 2 946 tis. Kč
    • •
  • GA ČR
Projekt

Molecular mechanism of GABA B receptor regulation by KCTD proteins (GA14-28334S)

GABA B receptor is the metabotropic receptor for the main inhibitory neurotransmitter GABA (γ-aminobutyric acid). It plays essential role in many physiological and pathophysiological states such as learning, memory, pain perception,...

FH - Neurologie, neurochirurgie, neurovědy

  • 2014 - 2018
    • •
  • 4 425 tis. Kč
    • •
  • 4 425 tis. Kč
    • •
  • GA ČR
Projekt

New steroid antiepileptics synthesis and biological activity (GA203/06/1605)

 Organic chemistry reacts to the need of positive allosteric modulators of g-aminobutyric acid by the synthesis of analogues of 3a-hydroxy-5a-pregnan-20-one ("allopregnanolone"). Most of them suffer from very fast metabolism, furthe...

CC - Organická chemie

  • 2006 - 2008
    • •
  • 2 082 tis. Kč
    • •
  • 2 082 tis. Kč
    • •
  • GA ČR
Projekt

The role of GABAB receptor-associated KCTD16 proteins in the sensory nervous system (GA21-17085S)

The γ-aminobutyric acid type B receptor (GABAB) regulates neuronal excitability through a variety of mechanisms, including the inhibition of presynaptic voltage-gated Ca2+ channels. Dysfunctions of the receptor have been implicated ...

Neurosciences (including psychophysiology)

  • 2021 - 2024
    • •
  • 9 536 tis. Kč
    • •
  • 9 452 tis. Kč
    • •
  • GA ČR
Projekt

The role of miRNA in development of glutamatergic and GABAergic signaling after early-life seizures (GA19-11931S)

of both glutamatergic and γ-aminobutyric acid (GABA)ergic pathways play crucial role...

Developmental biology

  • 2019 - 2022
    • •
  • 10 218 tis. Kč
    • •
  • 9 723 tis. Kč
    • •
  • GA ČR
Projekt

Purinergic P2X receptors and their role in suprachiasmatic nuclei of hypothalamus (IAA500110702)

The purinergic P2X receptors (P2XRs) represent a novel structural type of ligand-gated ion channel activated by extracellular ATP. So far 7 P2XR subunits have been found in excitable as well as non-excitable tissues. Little is known about their role ...

ED - Fyziologie

  • 2007 - 2009
    • •
  • 1 863 tis. Kč
    • •
  • 1 863 tis. Kč
    • •
  • AV ČR
Projekt

Fatty acid cycling by phosphate carrier and uncoupling protein 2. (ME 389)

Kinetic studies of fatty acid cycling and fatty acid interaction with mitochondrial phophate carrier and uncoupling protein 2 in the presence of various inhibitors. Location of the fatty acid binding site in their ...

EB - Genetika a molekulární biologie

  • 2000 - 2003
    • •
  • 1 780 tis. Kč
    • •
  • 1 100 tis. Kč
    • •
  • MŠMT
Projekt

Production of lactic acid bacteria minor non peptide metabolites with antimicrobial activity (MEB040705)

Publication of results in scientific refereed journals with attention to applies research: Food Control, Acta Alimentaria, Mlékařské listy. Presentations on scientific conferences, 2-2 PhD thesis work, diploma works Report for Minis...

GM - Potravinářství

  • 2008 - 2008
    • •
  • 69 tis. Kč
    • •
  • 69 tis. Kč
    • •
  • MŠMT
Projekt

Gels based on plant triterpenoid acids (FV10599)

1. Investigation and development of nanostructured gels of triterpenoid acids- 2. Investigation and development of methods of targeted derivation of triterpenoid acids focusing on improvement of the targeted characteristics...

CC - Organická chemie

  • 2016 - 2020
    • •
  • 10 197 tis. Kč
    • •
  • 7 843 tis. Kč
    • •
  • MPO
Projekt

Aditive effects of omega-3 polyunsaturated fatty acids and pioglitazone in the treatment of type 2 diabetes mellitus (NS10528)

Double-blind, randomised, placebo-controlled study aiming 1) to verify additive beneficial effects of the 6-month usage of the omega-3 fatty acids (n3FA), dosage of 5g tolerance and lipid metabolism of type 2 diabetics (T2D) treated...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2009 - 2011
    • •
  • 9 883 tis. Kč
    • •
  • 9 883 tis. Kč
    • •
  • MZ
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