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23 (0,075s) •

Projekt

The role of Ser/Thr protein kinase StkP in regulation of cell division in Streptococcus penumoniae (GAP302/12/0256)

Ser/Thr protein kinase StkP. Prior studies demonstrated that StkP regulates cell of StkP were identified to date including cell division protein DivIVA. The central hypothesis of this proposal is that StkP senses ...

EE - Mikrobiologie, virologie

  • 2012 - 2016
    • •
  • 7 895 tis. Kč
    • •
  • 7 895 tis. Kč
    • •
  • GA ČR
Projekt

Analysis of substrates of Ser/Thr protein kinase StkP in Streptococcus pneumoniae and impact of phosphorylation on their function (GP204/07/P082)

systems anda single eukaryotic-type serine/threonin protein kinase StkP. Gene inactivation showed that StkP positively controls virulence and competence in S. pneumoniae. One of potential StkP substrates is alpha-subunit o...

EE - Mikrobiologie, virologie

  • 2007 - 2009
    • •
  • 1 452 tis. Kč
    • •
  • 1 452 tis. Kč
    • •
  • GA ČR
Projekt

Regulation of pneumococcal cell division through protein phosphorylation (GA18-07748S)

-like shape. StkP, an important part of pneumococcal divisome, is an eukaryotic-type, only a few StkP substrates have been identified and characterized. Using enrichment as uncharacterized proteins are phosphorylated depending on

Microbiology

  • 2018 - 2021
    • •
  • 5 506 tis. Kč
    • •
  • 5 455 tis. Kč
    • •
  • GA ČR
Projekt

Functions and interactions of the proteinkinase StkP substrates involved in cell division of Streptococcus pneumoniae (GA19-03269S)

Ser/Thr proteinkinase StkP of S. pneumoniae is plays an important role in regulating cell-wall synthesis and controls correct septum progression and closure. StkP, we identified a new substrate of StkP as a novel cell div...

Microbiology

  • 2019 - 2022
    • •
  • 5 953 tis. Kč
    • •
  • 5 953 tis. Kč
    • •
  • GA ČR
Projekt

Genetic Analysis of Candidate Genes in Acute Myeloid Leukemias and Myelodyplastic Syndromes (NC5535)

with del(5q). The project will lead to understanding of melecular basis of AML and MDS with the del(5q) and,consequently,to introducing novel diagnostic and therapeutic......

FD - Onkologie a hematologie

  • 1999 - 2001
    • •
  • 4 419 tis. Kč
    • •
  • 4 394 tis. Kč
    • •
  • MZ
Projekt

Reconstruction of uplifting history in the Fuegian Andes cenhal belt (souttrem Tiera del Fuego, Argentina) (7AMB14AR026)

The aim of the proposed project is dating of the main tectonometamorphic phases and also reconstruction of low-temperature evolution of the eastern part of the Cordillera Darwin on Argentine territory of Tierra del Fuego and their comparison...

DB - Geologie a mineralogie

  • 2014 - 2015
    • •
  • 260 tis. Kč
    • •
  • 260 tis. Kč
    • •
  • MŠMT
Projekt

Structure and function of sensor domain of proteinkinase StkP and its relationship to cellular processes (GAP207/12/1568)

of StkP kinase and to determine amino acid residues involved in ligand binding affinity to the ligand molecules. Consequently, StkP-dependent signalling cascade......

CE - Biochemie

  • 2012 - 2015
    • •
  • 4 374 tis. Kč
    • •
  • 4 374 tis. Kč
    • •
  • GA ČR
Projekt

Re-emergent and novel players of intracellular signalling in Streptococcus pneumoniae (GA22-11062S)

/Thr proteinkinase StkP of S. pneumoniae plays an important role in regulating cell-wall synthesis and controls correct septum progression and closure. StkP signals of proteome profiles of stkP mutated strains showed coordi...

Microbiology

  • 2022 - 2024
    • •
  • 8 169 tis. Kč
    • •
  • 8 169 tis. Kč
    • •
  • GA ČR
Projekt

The role of DNA/RNA-binding proteins in cellular processes of S. pneumoniae (LUAUS25092)

Streptococcus pneumoniae is an important human pathogen that causes serious diseases and numerous deaths. The uniqueeukaryotic-type Ser/Thr protein kinase StkP and its antagonistic partner, the protein phosphatase PhpP, are critical on ...

Microbiology

  • 2025 - 2028
    • •
  • 7 718 tis. Kč
    • •
  • 7 718 tis. Kč
    • •
  • MŠMT
Projekt

Molecular and Cytogenetic Characterization of the Chromosome-5 long arm deletion ( del (5q) ) in patients with MDSand AML. (IZ2826)

FD - Onkologie a hematologie

  • 1995 - 1997
    • •
  • 2 285 tis. Kč
    • •
  • 2 285 tis. Kč
    • •
  • MZ
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