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Projekt

Interaction proteins with surfaces. New biophysical methods for analysis of tumor supressos protein p53 (GP202/07/P497)

The tumor suppressor protein plays a critical role in the control of cell division and development of cancer. Mutation can result in abolishing the tumor suppressor function of the p53 protein and enhance ...

BO - Biofyzika

  • 2007 - 2009
    • •
  • 1 164 tis. Kč
    • •
  • 1 164 tis. Kč
    • •
  • GA ČR
Projekt

Wild type and mutant p53 tumor suppressor protein. Intermolecular interactions, changes in conformation and new micro-methods of their analysis (IAA500040513)

The tumor suppressor protein p53 plays a critical role in the control of cell division and development of cancer. Mutation can result in abolishing the tumor suppressor function of the p53 protein and gain...

CE - Biochemie

  • 2005 - 2008
    • •
  • 2 930 tis. Kč
    • •
  • 2 930 tis. Kč
    • •
  • AV ČR
Projekt

Interactions of mutant p53 with genomic DNA in vitro and in vivo (1K04119)

The tumor suppressor gene p53 belongs to the most frequently mutated genes in genomic stability and control of transcription or replication will be characterized for the detection of DNA-protein interactions, computer analy...

EB - Genetika a molekulární biologie

  • 2004 - 2007
    • •
  • 2 672 tis. Kč
    • •
  • 2 420 tis. Kč
    • •
  • MŠMT
Projekt

Myb, Fos, Jun and retinoid receptor protein interactions in anti-leukemic processes (GA312/98/0679)

of powerful anti-tumor therapies. Proteins Myb, Jun, Fos a retinoid receptors belong with a complex signal network, which in healthy cells controls processes of diferentiation and proliferation of leukemic cells. The proje...

EB - Genetika a molekulární biologie

  • 1998 - 2000
    • •
  • 1 654 tis. Kč
    • •
  • 1 572 tis. Kč
    • •
  • GA ČR
Projekt

Mutants of tumor supressor protein p53 and regulation of thei DNA binding activity (KJB500040502)

The p53 tumor suppressor protein plays a critical role in the cellular response to DNA damage by regulating the expression of genes involved in controlling DNA repair, cell proliferation and apoptosis. Mutants of p53 pr...

EB - Genetika a molekulární biologie

  • 2005 - 2007
    • •
  • 1 230 tis. Kč
    • •
  • 1 230 tis. Kč
    • •
  • AV ČR
Projekt

Role of TCTP/Mmi1 in controlling protein degradation in yeast (7AMB14AT016)

Yeast protein Mmi1 is a homolog of the mammalian "translationally controlled tumor protein" (TCTP), which plays a critical role in controlling cell survival. Our-proteasome system and the Ubp3/Bre5 deubiqu...

EB - Genetika a molekulární biologie

  • 2014 - 2015
    • •
  • 136 tis. Kč
    • •
  • 136 tis. Kč
    • •
  • MŠMT
Projekt

Molecular basis of interaction between FOXO Forkhead transcription factors and tumor suppressor p53 (GA21-02080S)

of the interaction between Forkhead box O (FOXO) transcription factors and tumor suppressor p53. These proteins not only regulate diverse signaling pathways to control cell cycle, apoptosis the interaction between p53 and ...

Biochemistry and molecular biology

  • 2021 - 2024
    • •
  • 8 540 tis. Kč
    • •
  • 8 507 tis. Kč
    • •
  • GA ČR
Projekt

Development of experimental vaccine against WT 1 for immunotherapy of tumors (NS10660)

WT1 gene is highly expressed in myeloid leukemia and in some solid tumors. Eventhough WT1 is an autologous protein, it is immunogenic in humans and therefore it was evaluated as a promising target antigen for immunotherapy of tu...

FD - Onkologie a hematologie

  • 2009 - 2011
    • •
  • 10 317 tis. Kč
    • •
  • 10 317 tis. Kč
    • •
  • MZ
Projekt

Tumor stress-induced proteins as target structures for cytotoxic cells (IAA5020403)

of stress-induced proteins at tumor cell surface. In the current proposal we suggestto use biochemical and immunological methods to identify stress-induced proteins against experimentally induced tumors IN VIVO......

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2004 - 2008
    • •
  • 4 917 tis. Kč
    • •
  • 4 917 tis. Kč
    • •
  • AV ČR
Projekt

Tumor suppressor proteins of p53 family and chromosomal protein HMG1. A search for a functional link. (GA301/02/0952)

p53 is one of the most extensively studied genes. p53 is a crucial tumor of (down-stream) genes related to the cell-cycle control and programmed cell death-histone chromosomal protein with suggested roles in transcription, ...

EB - Genetika a molekulární biologie

  • 2002 - 2004
    • •
  • 3 664 tis. Kč
    • •
  • 1 947 tis. Kč
    • •
  • GA ČR
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