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Projekt

Androgenesis in vitro - New tool to Production of Breeding Material of Lolium spp., Festuce spp. and their Hybrids (EP0960996099)

Induction of androgenesis in intergeneric hybrids Festulolium obtained in breeding station Hladké Životice willbe used to obtain homozygous lines. The homozygous lines will be used to obtain hybrids with high heter...

GE - Šlechtění rostlin

  • 1996 - 2000
  • 3 757 tis. Kč
  • 3 543 tis. Kč
  • MZe
Projekt

The application of CRISPR-Cas9 for the creation of multiple mutants in the genes coding for the nascent polypeptide associated complex (LTC20050)

reproduction. Conventional Arabidopsis thaliana double homozygous mutant in the genes acquired by the cross of the available T-DNA insertion lines) showed notable phenotypic defects in the flowers and siliques. Moreover, seeds of t...

Plant sciences, botany

  • 2020 - 2023
  • 4 863 tis. Kč
  • 4 863 tis. Kč
  • MŠMT
Projekt

The use of progressive biotechnologic methods at breeding of oilseed poppy (TA01010375)

and streamline opium poppy breeding processes via the production of fully homozygous lines....

GE - Šlechtění rostlin

  • 2011 - 2014
  • 15 163 tis. Kč
  • 12 077 tis. Kč
  • TA ČR
Projekt

Targeted gene silencing in tomato plants using RNA interference against quarantine pathogen Tobacco Ringsot Virus (TRSV) (LTC18001)

the segregation of the T1 generation and select homozygous lines of tomato plant resistant...

GM technology (crops and livestock), livestock cloning, marker assisted selection, diagnostics (DNA chips and biosensing devices for the early/accurate detection of diseases) biomass feedstock production technologies, biopharming

  • 2018 - 2020
  • 2 604 tis. Kč
  • 2 604 tis. Kč
  • MŠMT
Projekt

Utilization of biotechnological methods and non-traditional genetic resources for the characterization and construction of uniform lines of cruciferous vegetables with specific parameters of quality (QK1910070)

The project represents a unique interconnection of academic, research and breeding facilities aimed at introducing modern methods into practical breeding of Brassica vegetables.The aim of the project is to optimize, introduce and use advanced procedu...

GM technology (crops and livestock), livestock cloning, marker assisted selection, diagnostics (DNA chips and biosensing devices for the early/accurate detection of diseases) biomass feedstock production technologies, biopharming

  • 2019 - 2023
  • 19 995 tis. Kč
  • 19 995 tis. Kč
  • MZe
Projekt

Molecular aspects of diagnostics and therapy of spinal muscular atrophy (1A8608)

Spinal muscular atrophy is autosomal-recessive disease caused in ca. 95% of cases by homozygous deletion of the SMN1 gene. The SMN1 gene and its SMN2 copy localise to chromosome 5q13. Differences between SMN1 and SMN2 result in different and...

FH - Neurologie, neurochirurgie, neurovědy

  • 2005 - 2008
  • 4 414 tis. Kč
  • 4 335 tis. Kč
  • MZ
Projekt

Novel test for classical and variant Niemann-Pick type C disease. Evaluation of pathogenicity of frequent NPC1 alleles implicated in late-onset NPC. (NV16-33923A)

skin fibroblast cell lines from patients with different forms of NPC; cholesterol/cholesteryl ester ratio will be calculated. Cell lines homozygous for frequent variants......

FH - Neurologie, neurochirurgie, neurovědy

  • 2016 - 2019
  • 5 589 tis. Kč
  • 5 589 tis. Kč
  • MZ
Projekt

Revealing the role of the nascent polypeptide associated complex during flower and fruit development of Arabidopsis thaliana (GA19-01723S)

Angiosperm flower and fruit development are regulated by the activity of many genes. The double homozygous mutant of the beta subunit of the nascent polypeptide associated complex (nacbeta -/-) was created by conventional crossing of two T-D...

Plant sciences, botany

  • 2019 - 2023
  • 6 905 tis. Kč
  • 6 905 tis. Kč
  • GA ČR
Projekt

A-204C polymorphism and regulation of cholesterol 7alpha-hydroxylase activity (NR8987)

Circadian variation in cholesterol 7alpha-hydroxylase (CYP7A1) activity will be studied in healthy volunteers homozygous either for -204A or -204C variant in CYP7A1 gene promoter. Circadian variation in CYP7A1 activity will be studied under ...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2006 - 2008
  • 3 917 tis. Kč
  • 3 599 tis. Kč
  • MZ
Projekt

The application of modern imaging techniques to reveal flower and male gametophyte development of Arabidopsis thaliana (LTC18043)

Angiosperm flower and fruit development are regulated by a common activity of a plethora of genes. The double homozygous Arabidopsis thaliana mutants in genes coding for beta subunits of nascent polypeptide-associated complex (NAC) showed no...

Plant sciences, botany

  • 2018 - 2020
  • 2 759 tis. Kč
  • 2 759 tis. Kč
  • MŠMT
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