Filtry
Pattern of DNA methylation in retroviral regulatory sequences (GA204/01/0632)
CpG methylation of proviral DNA is the key mechanism of transcriptional regulation of retroviruses by the host cell. We and others have obtained preliminary data that the sequence-specific pattern of methylation, i.e. the <...
EB - Genetika a molekulární biologie
- 2001 - 2003 •
- 4 657 tis. Kč •
- 2 210 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2001 - 1. 1. 2003
Uznané náklady
Podpora ze státního rozpočtu (47%)
Poskytovatel: Grantová agentura České republiky
Effects of the ectopic DNA methyltransferase expression on the transcription of integrated proviruses (IAA5052804)
into the genomes of rodent embryo fibroblasts and their DNA is densily methylated. In this line, in vitro methylated DNA of RSV LTR-driven reporter constructs upon transfection activity and the level, of overall c...
EE - Mikrobiologie, virologie
- 1998 - 2000 •
- 1 725 tis. Kč •
- 1 202 tis. Kč •
- AV ČR
Řešení projektu: 1. 1. 1998 - 1. 1. 2000
Uznané náklady
Podpora ze státního rozpočtu (70%)
Poskytovatel: Akademie věd České republiky
Application of DNA methylation arrays for assessment of aberrantly methylated genes in MDS and AML patients (OC10042)
, apoptosis, metastasis etc. The alterations of gene promoter methylation lead to uncontrolled proliferation of leukemic cells and malignant transformation. The DNA methylation changes can be used to detect leukemic cells i...
FD - Onkologie a hematologie
- 2010 - 2012 •
- 2 400 tis. Kč •
- 2 100 tis. Kč •
- MŠMT
Řešení projektu: 1. 5. 2010 - 30. 11. 2012
Uznané náklady
Podpora ze státního rozpočtu (88%)
Poskytovatel: Ministerstvo školství, mládeže a tělovýchovy
Impact of methylation pattern on multiple myeloma progression (NV18-03-00500)
mechanisms, such as DNA methylation are increasingly recognized as potent modulators to the diagnostics, the contribution of DNA methylation has been discovered as important. Specifically, we investigate the impac...
Genetics and heredity (medical genetics to be 3)
- 2018 - 2021 •
- 11 170 tis. Kč •
- 11 170 tis. Kč •
- MZ
Řešení projektu: 1. 5. 2018 - 31. 12. 2021
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
The relationship between the methylation status, structure and function of tobacco 5S rDNA locus (GA204/98/0191)
Genomic sequencing of all methylcytosine residues in the 5S rDNA loci of the Nicotiana tabcum genome will be used to map the methylation status of the DNA and study its maintenance. The methylation status either of the nati...
CE - Biochemie
- 1998 - 2000 •
- 3 536 tis. Kč •
- 2 466 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 1998 - 1. 1. 2000
Uznané náklady
Podpora ze státního rozpočtu (70%)
Poskytovatel: Grantová agentura České republiky
DNA methylation in heterogeneous populations of fish spermatozoa after their aging in vitro (GA23-06426S)
understanding of sperm aging in higher vertebrates as well. Sperm DNA methylation patterns of the DNA methylation pattern during sperm aging in heterogeneous population of motile level of genes involved in the dif...
Animal and dairy science; (Animal biotechnology to be 4.4)
- 2023 - 2025 •
- 8 312 tis. Kč •
- 8 070 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2023 - 31. 12. 2025
Uznané náklady
Podpora ze státního rozpočtu (97%)
Poskytovatel: Grantová agentura České republiky
Mechanisms of DNA methylation and demethylation in higher plants (GA204/99/D001)
to reveal principles of DNA methylation in different sequence motives in higher plant genomes. Inheritance of methylation patterns will be studied using experimentallyBisulfite genomic sequencing will be applied to study 5...
EB - Genetika a molekulární biologie
- 1999 - 2002 •
- 747 tis. Kč •
- 671 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 1999 - 1. 1. 2002
Uznané náklady
Podpora ze státního rozpočtu (90%)
Poskytovatel: Grantová agentura České republiky
Determination of SNP and DNA methylation profiles in patients with myelodysplatic syndrome by microarrays. (NS9634)
Annotation 1: The aim of the project is determination of SNP and DNA methylation profiles in MDS patients. Annotation 2: We will use Illumina microarrays, "Cancer SNP Panel" for detection of 1421 SNPs located in 408 genes and "M...
EB - Genetika a molekulární biologie
- 2008 - 2011 •
- 5 986 tis. Kč •
- 5 986 tis. Kč •
- MZ
Řešení projektu: 1. 7. 2008 - 31. 12. 2011
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
Overcoming the transcriptional inhibition of the Rous sarcoma virus in mammalian cells by the anti-methylation effects on the virus regulatory sequences (GA312/97/P082)
, and cytosine methylation of proviral DNA. Our project is aimed to gain some knowledge on the protection of integrated RSV proviruses from DNA methylation. Anti-methylation effects will be provided by ins...
EE - Mikrobiologie, virologie
- 1997 - 1999 •
- 640 tis. Kč •
- 530 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 1997 - 1. 1. 1999
Uznané náklady
Podpora ze státního rozpočtu (83%)
Poskytovatel: Grantová agentura České republiky
DNA methylation patterns during plant embryogenesis and seed germination (GA521/99/0696)
that DNA methylation plays an important control role in long-term trasciriptional regulation of gene expression and development. In this project we will analyse DNA and development. We expect dramatic changes in global
GE - Šlechtění rostlin
- 1999 - 2001 •
- 3 269 tis. Kč •
- 2 703 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 1999 - 1. 1. 2001
Uznané náklady
Podpora ze státního rozpočtu (83%)
Poskytovatel: Grantová agentura České republiky
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