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4 762 (0,111s) •

Projekt

The role of increased epoxyeicosatrienoic acids level in the regulation of renal function and pathophysiology of renovascular hypertension (NS9699)

This proposal is designed to determine whether inhibitors of soluble epoxide hydrolase (sEH), increasing endogenous level of epoxyeicosatrienoic acids (EETs), could be a potential new approach in antihypertensive drug therapy. An effects of novel sEH...

ED - Fyziologie

  • 2008 - 2011
    • •
  • 3 119 tis. Kč
    • •
  • 3 119 tis. Kč
    • •
  • MZ
Projekt

Bile salt malabsorption in patients with Crohn´s disease as a factor predisposing for pigment gallstone formation (NK7707)

Aim of the study is to assess the malabsorption of bile-acids in pts with Crohn´s disease as the predisposition factor of pigment cholelithiasis by detection of 7 alpha hydroxy-4-cholesten-3-ons in blood specimens.......

FP - Ostatní lékařské obory

  • 2003 - 2005
    • •
  • 1 785 tis. Kč
    • •
  • 1 746 tis. Kč
    • •
  • MZ
Projekt

Syntheses,reactions and biological activity of some derivates of 2- Quinolone (GA203/97/0033)

The intention of the Project is the preparation of a new type of heterocycles with antiproliferative activity accesible by the reaction of 3- and/or 4-oxo derivatives of 4- and/or 3-hydroxy-1,2,3,4,tetrahy...

CC - Organická chemie

  • 1997 - 1999
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  • 1 265 tis. Kč
    • •
  • 894 tis. Kč
    • •
  • GA ČR
Projekt

Syntheses of the 4 - substituted nucleoside carba analogs with potentional antiviral effects (GA203/97/0375)

in the position 4', and the analogs with substituted hydroxy group of the hydroxymethylIn continuation of the previous studies aimed at the syntheses of 4'-C-substituted deoxynucleosides with a potential antiviral activity...

CC - Organická chemie

  • 1997 - 1999
    • •
  • 920 tis. Kč
    • •
  • 322 tis. Kč
    • •
  • GA ČR
Projekt

Influence of individual factors on the levels of markers of oxidative stress in biological materials of subjects with exposure to asbestos and silica (NR9338)

Finding optimum methods for analysis of markers of oxidative stress in biological material - exhaled breath condensate, in blood and urine: 8-isoprostane, 4-hydroxy-trans-2-nonenal (HNE) and malondialdehyde (MDA) in subjects with su...

FE - Ostatní obory vnitřního lékařství

  • 2007 - 2009
    • •
  • 4 888 tis. Kč
    • •
  • 4 777 tis. Kč
    • •
  • MZ
Projekt

Phase interface properties in nanoaggregates and their influence on chemical reactivity (GA203/04/0488)

The rate of diphenyl 4-nitrophenyl phosphate (PNPDPP) hydrolysis catalyzed by amphiphilic pyridinium ketoximes in micelles of cationic or non-ionic surfactants or in o-yl ketoximes was proposed as a probe for the interface dynamics ...

CC - Organická chemie

  • 2004 - 2006
    • •
  • 587 tis. Kč
    • •
  • 587 tis. Kč
    • •
  • GA ČR
Projekt

Intramolecular Nucleophilic Substitution. Kinetics and Mechanism of the Tandem Recyclization Reaction (GP203/02/D170)

The aim of the submitted project is a study of kinetics and mechanism of tandem recyclation reaction of substituted S-(1-phenylpyrrolidin-2-on-3-yl)isothiuronium salts to the corresponding 2-imino-5-[2-(phenylamino)ethyl]thiazolidin...

CC - Organická chemie

  • 2002 - 2004
    • •
  • 1 100 tis. Kč
    • •
  • 250 tis. Kč
    • •
  • GA ČR
Projekt

*Colourless UV fluorescent pigments (FR-TI1/152)

*Searching, synthesis research and its up-scaling aimed on colourless UV fluorescent pigments for application area as pigment markers utilised for Invisible Security & Anti-Counterfeiting.......

CC - Organická chemie

  • 2009 - 2013
    • •
  • 15 366 tis. Kč
    • •
  • 5 512 tis. Kč
    • •
  • MPO
Projekt

3-Hydroxyquinolin-4(1H)-ones as biologically interesting molecules (GJ18-26557Y)

The project deals with 3-hydroxyquinolin-4(1H)-ones (3-HQs) as compounds are discussed. It was found out that some 3-HQ derivatives interact with translation of the project describes conjugates of 3-HQs wi...

Organic chemistry

  • 2018 - 2020
    • •
  • 4 620 tis. Kč
    • •
  • 4 620 tis. Kč
    • •
  • GA ČR
Projekt

New biological aktive heterocycles the on basis of quinolin-2,4-diones (GP203/07/P266)

in position 3 is the main aim of this project. At first thiazoloquinoline from 3-thiocyanatoquinoline will be prepared. In the case of the 3-thiocyanatoquinolines which do not contain the substituent in position 3...

CC - Organická chemie

  • 2007 - 2009
    • •
  • 394 tis. Kč
    • •
  • 394 tis. Kč
    • •
  • GA ČR
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