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Projekt

Water-soluble fluorinated polymers for the next-generation antifouling coatings and multimodal in vivo tracing (GA22-02836S)

for inorganic nanoparticles that enable their simultaneous 19F MRI/fluorescence tracing with the best 19F MRI and antifouling properties. The selected polymers will then be used be effectively used as multimodal <...

Nano-materials (production and properties)

  • 2022 - 2024
    • •
  • 9 614 tis. Kč
    • •
  • 9 614 tis. Kč
    • •
  • GA ČR
Projekt

Complexes of fluorinated ligands with paramagnetic metal ions for 19F MRI and bimodal 1H/19F contrast agents (GA22-34083S)

CAs with the 19F CAs as such bimodal 1H/19F MRI CAs can be used for dual imagingMRI is common imaging methods in medicine. To improve resolution, contrast agents (MRI CAs) based mainly on complexes of Gd(...

Inorganic and nuclear chemistry

  • 2022 - 2024
    • •
  • 5 991 tis. Kč
    • •
  • 5 991 tis. Kč
    • •
  • GA ČR
Projekt

MRI diagnostic markers in Cushing´s disease (NT13631)

MRI. The sensitivity and specificity of the new sequences will be assessed are influenced by preoperative magnetic resonance imaging (MRI).Conventional MRI, however, is not sufficiently sensitive and spec...

FH - Neurologie, neurochirurgie, neurovědy

  • 2012 - 2015
    • •
  • 3 243 tis. Kč
    • •
  • 3 075 tis. Kč
    • •
  • MZ
Projekt

Paramagnetic switches in polymer contrast agents for 19F and 31P magnetic resonance The new paradigm in noninvasive cancer functional imaging (LTC19032)

The aim of this project is to develop a conceptually new class of cancer-aimed biodegradable phosphorus or fluorine-containing polymer contrast agents for 1H / 31P or 1H / 19F magnetic resonance (MR) providing both anatomical (1H MR) and fu...

Polymer science

  • 2019 - 2022
    • •
  • 4 920 tis. Kč
    • •
  • 4 920 tis. Kč
    • •
  • MŠMT
Projekt

New bimodal nano-structures for combined diagnostics and therapeutics (LD13048)

will be developed for MRI scanners which are available in the proposer´s laboratory for routine...

FP - Ostatní lékařské obory

  • 2013 - 2015
    • •
  • 1 154 tis. Kč
    • •
  • 1 154 tis. Kč
    • •
  • MŠMT
Projekt

REM sleep behavior disorder predicting the risk of neurodegeneration (GA16-07879S)

, instrumented gait analysis), advanced MRI (neuromelanin-sensitive imaging, quantitative (DaTSCAN, olfactory testing, color sensitivity, cognition, electroencehalography detects abnormalities in the earliest iRBD stage and...

FH - Neurologie, neurochirurgie, neurovědy

  • 2016 - 2020
    • •
  • 7 179 tis. Kč
    • •
  • 7 179 tis. Kč
    • •
  • GA ČR
Projekt

The use of MRI spectroscopy in the guiding of biopsy in supratentorial gliomas (NT12254)

The choice of therapeutic strategy in supratentorial gliomas depends on histopathological diagnosis and results of neuroimaging, usually magnetic resonance (MRI). A conventional MRI is neither sensitive, nor specific enough...

FH - Neurologie, neurochirurgie, neurovědy

  • 2011 - 2015
    • •
  • 5 184 tis. Kč
    • •
  • 5 184 tis. Kč
    • •
  • MZ
Projekt

Selective NMR labelling as a tool for characterization of protein complexes involved in neurodegenerative diseases. (LTAUSA18168)

The aim of the project is implementation of methodology of solution fluorine 19F NMR for study of tau and Map2c proteins and its utilization in three areas: 1) Characterization of phosphorylation effect on 19F NMR signals. 2) Study ...

Biochemistry and molecular biology

  • 2019 - 2022
    • •
  • 6 620 tis. Kč
    • •
  • 6 620 tis. Kč
    • •
  • MŠMT
Projekt

Significance of 18F-FDG PET/CT, whole body MRI and 99mTc-MIBI scintigraphy in diagnosis, clinical staging and monitoring of course of multiple myeloma (NR9489)

Evaluation of the significance, specificity and sensitivity of 18F-FDG PET/CT, 99mTc-MIBI scintigraphy and whole body MRI of the skeleton in diagnostics, assessment of the degree, location and activity of multiple myeloma (MM). Comp...

FD - Onkologie a hematologie

  • 2007 - 2010
    • •
  • 2 915 tis. Kč
    • •
  • 2 812 tis. Kč
    • •
  • MZ
Projekt

Advanced magnetic resonance techniques to disclose pathophysiology and improve diagnosis and clinical management of degenerative cervical cord compression (NV18-04-00159)

). Routine MRI techniques could detect spinal cord compression, but not to distinguish DCM and NMDCCC. Advanced MR techniques, such as diffusion MRI and magnetic 3T scanner along with novel MRI/MRS techniques in a cohort of...

Clinical neurology

  • 2018 - 2021
    • •
  • 16 215 tis. Kč
    • •
  • 16 215 tis. Kč
    • •
  • MZ
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