Filtry
Identification of protein complexes associated with genotoxic RNA DNA hybrids and their role in maintenance of genomic stability (LH14037)
The aim of this project is to prepare tools for the isolation of proteins associated with R-loops, identify proteins associated with these structures under different conditions promoting transcription/replication collision and R-loop formation and va...
EB - Genetika a molekulární biologie
- 2014 - 2016 •
- 1 823 tis. Kč •
- 1 823 tis. Kč •
- MŠMT
Řešení projektu: 11. 4. 2014 - 31. 12. 2016
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo školství, mládeže a tělovýchovy
The Dynamic World of Telomeres Unraveling Evolutionary Innovations in Genome Stability (GA25-15566S)
The project investigates the diversity and evolution of telomere maintenance mechanisms across eukaryotes, focusing on genome stability. Through bioinformatic and their maintenance mechanisms, compare telomerase-dependent a...
Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology
- 2025 - 2028 •
- 12 829 tis. Kč •
- 12 829 tis. Kč •
- GA ČR
Řešení projektu: 1. 3. 2025 - 31. 12. 2028
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Fission yeast CSL proteins in the maintenance of genome integrity (GPP305/12/P040)
in the maintenance of genome stability in fission yeast, a favourite model for DNA repair. The proposed research will provide novel functional insight into the maintenance of genome in CSL deletion mutants. We wil...
EB - Genetika a molekulární biologie
- 2012 - 2014 •
- 3 426 tis. Kč •
- 3 426 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2012 - 31. 12. 2014
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Cytonuclear interactions in plant auto- and allopolyploids (GA22-03731S)
genes without directly altering the dosage of the cytosolic genomes, cytonuclear.). Besides the maintenance of the well-tuned cytonuclear interactions, another challenge of biparentally inherited nuclear genome and gen...
Genetics and heredity (medical genetics to be 3)
- 2022 - 2024 •
- 5 302 tis. Kč •
- 5 302 tis. Kč •
- GA ČR
Řešení projektu: 1. 4. 2022 - 31. 12. 2024
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
The relationship between the methylation status, structure and function of tobacco 5S rDNA locus (GA204/98/0191)
Genomic sequencing of all methylcytosine residues in the 5S rDNA loci of the Nicotiana tabcum genome will be used to map the methylation status of the DNA and study its maintenance. The methylation status either of the nati...
CE - Biochemie
- 1998 - 2000 •
- 3 536 tis. Kč •
- 2 466 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 1998 - 1. 1. 2000
Uznané náklady
Podpora ze státního rozpočtu (70%)
Poskytovatel: Grantová agentura České republiky
Role of Nse1/Nse3/Nse4, E3-ubiquitin ligase, in genome stability (GA18-02067S)
Genome and chromosome instabilities are the major factors in cancer progression. Three conserved eukaryotic SMC (Structural Maintenance of Chromosomes) complexes play crucial roles in different aspects of genome stability a...
Cell biology
- 2018 - 2022 •
- 7 276 tis. Kč •
- 6 790 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2018 - 31. 12. 2022
Uznané náklady
Podpora ze státního rozpočtu (93%)
Poskytovatel: Grantová agentura České republiky
Exploring the role of PML nucleolar compartment in rDNA maintenance in normal and cancer cells (GA23-07273S)
PML is a well-known cancer-suppressor that regulates apoptosis and angiogenesis and is involved in genome maintenance by regulating homologous recombination repair and alternative lengthening of telomeres. Genes coding human rDNA ar...
Cell biology
- 2023 - 2025 •
- 6 870 tis. Kč •
- 6 870 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2023 - 31. 12. 2025
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Role of DNA clamp complexes in the maintenance of genome stability in Arabidopsis (GA25-15186S)
of genome stability in plants. Therefore, the teams of A. Pečinka (IEB) and M functional understanding of the role of the DNA clamp complexes in the maintenance of plant genome stability during replicative and genotoxic st...
Plant sciences, botany
- 2025 - 2027 •
- 9 975 tis. Kč •
- 9 975 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2025 - 31. 12. 2027
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Role of Condensin II Complex in the DNA Damage Repair of Arabidopsis thaliana (GA22-00871S)
involved in the maintenance of genome stability in Arabidopsis thaliana. This complexPreserving genome stability is an intricate affair involving a dynamic the frequency of homologous recombination at different genomic...
Genetics and heredity (medical genetics to be 3)
- 2022 - 2024 •
- 7 733 tis. Kč •
- 7 733 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2022 - 31. 12. 2024
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Study of molecular mechanisms involved in suppression of transcription-associated genomic instability (GA17-02080S)
in the maintenance of genomic stability. We anticipate that this study will reveal new biomarkersDNA transcription can induce genomic instability by causing collapse of replication forks, especially under conditions of rep...
EB - Genetika a molekulární biologie
- 2017 - 2019 •
- 9 174 tis. Kč •
- 7 836 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2017 - 31. 12. 2019
Uznané náklady
Podpora ze státního rozpočtu (85%)
Poskytovatel: Grantová agentura České republiky
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