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Výsledek výzkumu

Basis for preclinical testing of MCN 5668-11C

Biodistribution studies of the preparation McN5652-11C on rats served for preclinics of this product which should be after the necessary clinical studies produced for diagnosis of psychiatric diseases using PET camera....

CH - Jaderná a kvantová chemie, fotochemie

  • 2008
  • Ztech
Výsledek výzkumu

Study of biological behaviour of iron oxide nanoparticles labelled with Fe-59 in rats

Biodistribution and elimination characteristics of iron oxide nanoparticles labelled with Fe-59 after intravenous and intraperitoneal administration to rats were studied....

FR - Farmakologie a lékárnická chemie

  • 2015
  • Vsouhrn
Výsledek výzkumu

Preclinical evaluation of radiolabelled nimotuzumab, a promising monoclonal antibody targeting the epidermal growth factor receptor

biodistribution profile in preclinical experiments. Methods Nimotuzumab was labelled with 131I studies, two cell lines (HaCaT and A431) were used. Biodistribution studies were......

FR - Farmakologie a lékárnická chemie

  • 2013
  • Jx
  • Odkaz
Výsledek výzkumu

Lanreotide labeled with 99mTc: Preparation, preclinical testing and comparison with 111In-DTPA-octreotide

Labeling of somatostatin receptor-specific peptide lanreotide with Tc-99m by a direct method and the analysis of its biodistribution in rats......

FR - Farmakologie a lékárnická chemie

  • 2002
  • Jx
Výsledek výzkumu

Preclinical evaluation of two newly developed somatostatin analogs labeled with indium and yttrium

Biodistribution profiles and elimination mechanisms in rats of two new octreotate derivatives radiolabeled with radioindium and radioyttrium were analysed....

FR - Farmakologie a lékárnická chemie

  • 2002
  • Jx
Výsledek výzkumu

Labeling of a bifunctional monophosphinic acid DOTA analogue with In-111: Radiochemical aspects and preclinical results

The complex formation of the monophosphinic analogue of DOTA bearing 4-aminobenzyl group with In-111 at a trace level was analyzed. Pharmacokinetics and biodistribution of the complex was studied in rats....

CA - Anorganická chemie

  • 2007
  • Jx
Výsledek výzkumu

Preclinical evaluation of radiolabeled peptides for PET imaging of glioblastoma multiforme

Glioblastoma multiforme (GBM) is an aggressive primary brain tumor and, despite the current intensive therapy regimen, median overall survival period is only 16–21 months from the date of diagnosis. Therefore, early and precise diagnosis of GBM is a ...

Biochemistry and molecular biology

  • 2019
  • Jimp
  • Odkaz
Výsledek výzkumu

Preclinical evaluation of gastrin derivatives labelled with In-111: Radiolabelling, affinity profile and pharmacokinetics in rats

linked to metal chelating DOTA in preclinical experiments. The radiolabelled peptides in receptor affinity. This biodistribution study in rats showed a rapid decrease in blood......

FR - Farmakologie a lékárnická chemie

  • 2014
  • Jx
  • Odkaz
Výsledek výzkumu

99m-Tc demotate 1: biodistribution and elimination characteristics in rats

Study of biodistribution a nd bioelimination of technetiem-99m labelled N-4 derivative of Tyr(3)-octreotate in rats, detailed study of biodistribution in rat kidney......

CF - Fyzikální chemie a teoretická chemie

  • 2005
  • Jx
Výsledek výzkumu

Development of PSMA-1007-Related Series of F-18-Labeled Glu-Ureido-Type PSMA Inhibitors

In recent years, a number of drugs targeting the prostate-specific membrane antigen (PSMA) have become important tools in the diagnosis and treatment of prostate cancer. In the present work, we report on the synthesis and preclinical evaluat...

Medicinal chemistry

  • 2020
  • Jimp
  • Odkaz
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