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Výsledek výzkumu

Stem Cell Transcription Factor Sox2 Is Expressed in a Subset of Folliculo-stellate Cells of Growth Hormone-Producing Pituitary Neuroendocrine Tumours and Its Expression Shows No Association

Sox2 is one of the transcription factors responsible for the maintenance of Sox2 expression in histological sections, we performed immunohistochemical detection of Sox2 in 113 pituitary neuroendocrine tumours from 109 patie...

Neurosciences (including psychophysiology)

  • 2020
  • Jimp
  • Odkaz
Výsledek výzkumu

Early ear neuronal development, but not olfactory or lens development, can proceed without SOX2

SOX2 is essential for maintaining neurosensory stem cell properties, although unclear. To address this, we used Foxgl-Cre to conditionally delete Sox2 during eye, ear, and olfactory placode development. Foxgl-Cre mediated early dele...

Neurosciences (including psychophysiology)

  • 2020
  • Jimp
  • Odkaz
Výsledek výzkumu

Incomplete and delayed Sox2 deletion defines residual ear neurosensory development and maintenance

The role of Sox2 in neurosensory development is not yet fully understood. Using mice with conditional Islet1-cre mediated deletion of Sox2, we explored the function of Sox2 in neurosensory development in a model with limite...

EB - Genetika a molekulární biologie

  • 2016
  • Jx
  • Odkaz
Výsledek výzkumu

Revitalising the rudimentary replacement dentition in the mouse

the stem/progenitor marker Sox2 and has activated Wnt/beta-catenin signalling at its Sox2-positive cells, but no Wnt/beta-catenin signalling. Here, we show of the RSDL and formation of lingually positioned teeth. Although Sox2<...

Developmental biology

  • 2019
  • Jimp
  • Odkaz
Výsledek výzkumu

Antitumor DNA vaccination against the Sox2 transcription factor

an experimental DNA vaccine against the transcription factor Sox2 that is importantfor self...

FD - Onkologie a hematologie

  • 2014
  • Jx
  • Odkaz
Výsledek výzkumu

Unique expression patterns of the embryonal stem cell marker SOX2 and hormone receptors suggest the existence of a subpopulation of epithelial stem/progenitor cells in porcine and bovine endometrium

SOX2. METHODS: A total of 24 endometrial tissue samples obtained from cycling pigs were determined. RESULTS: Inverse expression patterns of SOX2 and progesterone diffuse SOX2 expression was detected in the basal portions o...

Pathology

  • 2022
  • Jimp
  • Odkaz
Výsledek výzkumu

Cancer stem cell markers in pediatric sarcomas: Sox2 is associated with tumorigenicity in immunodeficient mice

between the expression of the transcription factor Sox2 and the tumorigenicity of the cell lines in immunodeficient mice: the Sox2 levels were highest in the two cell lines that were demonstrated as tumorigenic. Furthermore, So...

FD - Onkologie a hematologie

  • 2016
  • Jx
  • Odkaz
Výsledek výzkumu

Cancer stem cells in sarcomas: Getting to the stemness core.

pathological reprogramming. Transcription factor Sox2, which is frequently upregulated and maintenance of the CSC phenotype has been demonstrated in various sarcomas. Sox2 is a core. Fluorescence protein-based reporters of Sox2...

Oncology

  • 2018
  • Jimp
  • Odkaz
Výsledek výzkumu

Neural Differentiation of Mouse Embryonic Stem Cells-An in vitro Approach to Profile DNA Methylation of Reprogramming Factor Sox2-SRR2

Sox2 is one of the core transcription factors maintaining the embryonic stem lineage-specific differentiations. This study investigated the DNA methylation of Sox2, Nanog and Sox2 showed the existence of neural phenotype in...

Genetics and heredity (medical genetics to be 3)

  • 2021
  • Jimp
  • Odkaz
Výsledek výzkumu

Cancer stem cells in sarcomas: Getting to the sternness core

. Transcription factor Sox2, which is frequently upregulated in sarcomas, is directly involved has been demonstrated in various sarcomas. General significance: Sox2 is a core. Fluorescence protein-based reporters of Sox2 ex...

Biochemistry and molecular biology

  • 2018
  • Jimp
  • Odkaz
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