Filtry
Analysis of the mechanisms,that are responsible for functional inactivation of p53 protein in different tumout types. (IZ3477)
FD - Onkologie a hematologie
- 1996 - 1998 •
- 2 508 tis. Kč •
- 2 466 tis. Kč •
- MZ
Řešení projektu: 1. 1. 1996 - 1. 1. 1998
Uznané náklady
Podpora ze státního rozpočtu (98%)
Poskytovatel: Ministerstvo zdravotnictví
Mechanism of non-mutational p53 inactivation in human cancers and its implication for cancer therapy (GJ19-18177Y)
inactivation are unknown. To identify essential factors that govern p53 function, we and identify the mechanism of inactivation for candidate genes. The failure in regulating HDM2 and HDMX proteins from a new point of view...
Oncology
- 2019 - 2022 •
- 7 281 tis. Kč •
- 7 281 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2019 - 31. 12. 2022
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Protein factors regulating assembly and repair of the Photosystem II complex in cyanobacteria (GAP501/11/0377)
(PSII), the protein complex responsible for oxidation of water. PSII exhibits to a frequent light-induced inactivation. This is counteracted either by repair based protein factors which are just transiently associated with...
ED - Fyziologie
- 2011 - 2015 •
- 6 444 tis. Kč •
- 6 444 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2011 - 31. 12. 2015
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
The role of trans-translation in cellular differentiation and resistance to produced antibiotics in Streptomycetes (GA203/05/0106)
in a quality control of protein synthesis known as trans translation. Strains lacking ssrA containing antibiotic resistance marker or by one step inactivation of ssrA gene using in expression of proteins of the de...
CE - Biochemie
- 2005 - 2007 •
- 1 759 tis. Kč •
- 1 759 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2005 - 31. 12. 2007
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Cytokinin deactivation in Arabidopsis thaliana – different roles of cytokinin glycosyltransferases isoforms? (GPP501/12/P160)
Plant hormones cytokinins (CKs) are inactivated by action of UDP capable to inactivate CKs. It was found that these isoforms are expressed differently. These findings suggest different roles of the UGTs in the cytokinins inactiv...
CE - Biochemie
- 2012 - 2017 •
- 1 544 tis. Kč •
- 1 544 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2012 - 7. 12. 2017
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
The influence of X-inactivation on phenotype in comon X-linked metabolic disorder, its tissue distribution and inheritance (NR8361)
: We will search families with X-inactivation skewing to find out if the skewing is inherited in some families. We will study the inactivation by the HUMARA difference in X-inactivation. This will help to better interpretat...
EB - Genetika a molekulární biologie
- 2005 - 2007 •
- 3 901 tis. Kč •
- 3 869 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2005 - 31. 12. 2007
Uznané náklady
Podpora ze státního rozpočtu (99%)
Poskytovatel: Ministerstvo zdravotnictví
Genomic analysis of galactose transport protein degradation in the yeast Saccharomyces cerevisiae (GA204/05/2578)
and of several sugar-specific transport proteins by a mechanism known as catabolite inactivation or catabolite degradation. The essence of this process is the covalent modification of the key proteins of the above prot...
EB - Genetika a molekulární biologie
- 2005 - 2007 •
- 1 417 tis. Kč •
- 1 417 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2005 - 31. 12. 2007
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Interaction of oxygen free radicals with nitric oxide in the development of endothelial dysfunction in hypertension (NR7786)
+ handling. Synthesis and inactivation of nitric oxide (NO) will be measured in various in NO inactivation and formation of toxic peroxynitrate in various forms of hypertension in order......
FA - Kardiovaskulární nemoci včetně kardiochirurgie
- 2004 - 2006 •
- 7 239 tis. Kč •
- 2 280 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2004 - 1. 1. 2006
Uznané náklady
Podpora ze státního rozpočtu (31%)
Poskytovatel: Ministerstvo zdravotnictví
Sensitisation of B-CLL cells to cytostatics by monoclonal antibody rituximab - identification of responsible proteins (NR9301)
by inactivation of p53 or deletion of ATM 3. We assume to identify the responsible proteins spectrometry protein identification. 4. These identified proteins could serve......
EB - Genetika a molekulární biologie
- 2007 - 2009 •
- 1 785 tis. Kč •
- 1 507 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2007 - 31. 12. 2009
Uznané náklady
Podpora ze státního rozpočtu (84%)
Poskytovatel: Ministerstvo zdravotnictví
Role of chromatin remodeling proteins in hematopoietic stem cells and leukemogenesis (LH15170)
The proposed results include: a) new gene-inactivated and b) transgenic models to study chromatin-remodeling gene Smarca5 (Snfa2h) in mouse. The results are primarily academic such as the new knowledge of a) what mechanisms utilize Smarca5 d...
EB - Genetika a molekulární biologie
- 2015 - 2017 •
- 1 985 tis. Kč •
- 1 985 tis. Kč •
- MŠMT
Řešení projektu: 1. 11. 2015 - 31. 12. 2017
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo školství, mládeže a tělovýchovy
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