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36 048 (0,164s)

Výsledek výzkumu

Early recruitment of PARP-dependent m(8)A RNA methylation at DNA lesions is subsequently accompanied by active DNA demethylation

RNA methylation, especially 6-methyladenosine (m(6)A)-modified RNAs, plays after microirradiation. Interestingly, the level of m(8)A RNA at genomic lesions at microirradiated chromatin. PARPi abrogated not...

Biochemistry and molecular biology

  • 2022
  • Jimp
  • Odkaz
Výsledek výzkumu

N-6-Adenosine Methylation in RNA and a Reduced m(3)G/TMG Level in Non-Coding RNAs Appear at Microirradiation-Induced DNA Lesions

of RNA polymerases I and II did not affect the m(6)A RNA level at the irradiated genomic regions. After genome injury, m(6)A RNAs either diffused to the damaged the METTL16 enzyme, responsible for m

Cell biology

  • 2020
  • Jimp
  • Odkaz
Výsledek výzkumu

RIP-seq reveals RNAs that interact with RNA polymerase and primary sigma factors in bacteria

Bacteria have evolved structured RNAs that can associate with RNA polymerase (RNAP). Two of them have been known so far-6S RNA and Ms1 RNA but it is unclear if any other types of RNAs binding to RNAP exist...

Microbiology

  • 2024
  • Jimp
  • Odkaz
Výsledek výzkumu

The comprehensive interactomes of human adenosine RNA methyltransferases and demethylases reveal distinct functional and regulatory features

N6-methyladenosine (m(6)A) and N6,2 '-O-dimethyladenosine (m(6)Am) are two of RNA biology. They function mainly by regulating interactions with specific RNA in nascent RNA synthesis by RNA polymer...

Biochemistry and molecular biology

  • 2021
  • Jimp
  • Odkaz
Výsledek výzkumu

The role of RNA adenosine demethylases in the control of gene expression

RNA modifications are being recognized as an essential factor in gene, differentiation and disease. In eukaryotic mRNAs, N-6-adenosine methylation (m(6)A) is the most prevalent internal chemical modification identified to date. The ...

Biochemistry and molecular biology

  • 2019
  • Jimp
  • Odkaz
Výsledek výzkumu

Arabidopsis thaliana NudiXes have RNA-decapping activity

Recent discoveries of various noncanonical RNA caps, such as dinucleoside domains of life have led to a revision of views on RNA cap function and metabolism to a nucleoside are the strongest candidates for degradation of noncanonica...

Biochemistry and molecular biology

  • 2023
  • Jimp
  • Odkaz
Výsledek výzkumu

N6-methyladenosine demethylase FTO targets pre-mRNAs and regulates alternative splicing and 3'-end processing

N6-methyladenosine (m(6)A) is the most abundant base modification found in messenger RNAs (mRNAs). The discovery of FTO as the first m6A mRNA demethylase established the concept of reversible RNA modification. Here, we pres...

Biochemistry and molecular biology

  • 2017
  • Jimp
  • Odkaz
Výsledek výzkumu

The G-Patch Domain of Mason-Pfizer Monkey Virus Is a Part of Reverse Transcriptase

of the GPDhad no effect on M-PMV proteolytic polyprotein processing, assembly and RNAMason Pfizer monkey virus (M-PMV), like some other betaretroviruses, encodes in a drop in M-PMV infectivity. Immunoprecipitation...

CE - Biochemie

  • 2012
  • Jx
  • Odkaz
Výsledek výzkumu

Nucleic Acid Binding by Mason-Pfizer Monkey Virus CA Promotes Virus Assembly and Genome Packaging

have introduced mutations into the RKK region in both bacterial and proviral M-PMV vectors and have assessed their impact on M-PMV assembly, structure, RNA binding) domains and RNA. Specific interactions between N...

EE - Mikrobiologie, virologie

  • 2016
  • Jx
  • Odkaz
Výsledek výzkumu

Molecular Simulations to Investigate the Impact of N6-Methylation in RNA Recognition: Improving Accuracy and Precision of Binding Free Energy Prediction

N6-Methyladenosine (m(6)A) is a prevalent RNA post-transcriptional modification that plays crucial roles in RNA stability, structural dynamics, and interactions the stabilization induced by m(6)A on the free energy...

Physical chemistry

  • 2024
  • Jimp
  • Odkaz
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