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Projekt

Psychoplastogenicity of psilocybin – the interplay of serotonergic mechanisms, sleep–wake cycle and neuroplasticity on memory consolidation (GA20-25349S)

Serotonergic psychedelic psilocybin is currently extensively studied as a so-called fast-acting antidepressant in the indication of pharmacoresistant depression. One of the most likely mechanisms leading to an antidepressant effect ...

Neurosciences (including psychophysiology)

  • 2020 - 2023
    • •
  • 11 968 tis. Kč
    • •
  • 11 896 tis. Kč
    • •
  • GA ČR
Projekt

Application of research methods to design a system of services for psychedelic users (TJ02000156)

The main objective of the project is to explore the use of psychedelic substances in the Czech Republic using research methods and to reflect the results in the development of strategic documents on drug policy and services system at nationa...

Epidemiology

  • 2019 - 2021
    • •
  • 2 179 tis. Kč
    • •
  • 1 609 tis. Kč
    • •
  • TA ČR
Projekt

Serotonergic Mechanisms of Anxiety Pharmacological Studies in Agonistic Behaviour (IA70852)

9G - 9

  • 1992 - 1994
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  • 0 tis. Kč
    • •
  • 0 tis. Kč
    • •
  • AV ČR
Projekt

Psilocybin versus ketamine – fast acting antidepressant strategies in treatment-resistant depression (NU21-04-00307)

with serotonergic psychedelics psilocybin and ayahuasca describe the significant antidepressantDepression is the 4 most common cause of disability worldwide, with 20-30% of patients fulfilling the criteria for treatment-resistant d...

Psychiatry

  • 2021 - 2025
    • •
  • 15 038 tis. Kč
    • •
  • 12 699 tis. Kč
    • •
  • MZ
Projekt

The deficit of cognitive function in scizophrenia and central serotonergic activity (NF6033)

The relationship betwen serotonin, neurocognitive deficit and regional brain activity will be elucidated by the use of tryptophan depletion, functional magnetic resonance and neurocognitive testing. We will compare the group of healthy volunteers and...

FH - Neurologie, neurochirurgie, neurovědy

  • 2000 - 2002
    • •
  • 3 082 tis. Kč
    • •
  • 3 082 tis. Kč
    • •
  • MZ
Projekt

Study of metabolism of synthetic psychedelic amines as new toxic agents in clinical and forensic toxicology (NR8332)

The biotransformation of selected illegal synthetic drugs will be studied using toxicological methods based on GC-MS. After administration of toxic agents to experimental rats, excreted urine will be collected, and structure of metabolites determined...

FR - Farmakologie a lékárnická chemie

  • 2005 - 2007
    • •
  • 1 431 tis. Kč
    • •
  • 1 431 tis. Kč
    • •
  • MZ
Projekt

Role of metabotropic mGlu2/3 a AMPA glutamatergic receptors in neurobiology of schizophrenia (NS10375)

in pharmacological serotonergic model of psychosis (2C-B) 6. the influence of ionotropic changes in pharmacological serotonergic model of psychosis (2C-B)......

FL - Psychiatrie, sexuologie

  • 2009 - 2011
    • •
  • 5 059 tis. Kč
    • •
  • 5 059 tis. Kč
    • •
  • MZ
Projekt

From Magic to Pharmaceutical Drugs Using Psychoactive Mushrooms (LUAIZ24146)

Psychedelics, with mushrooms containing psilocybin in the first line, are gaining robust evidence as novel hot candidates in the treatment of several psychiatric disorders. The specific aims of this study are 1. Development of optimized/psil...

Psychology (including human - machine relations)

  • 2024 - 2027
    • •
  • 2 716 tis. Kč
    • •
  • 2 399 tis. Kč
    • •
  • MŠMT
Projekt

RAFAEL Regression of atherosclerosis induced by life changing experience with psilocybin (LUAUS24162)

and emotional stress using psychedelic-assisted psychoterapy . A secondary aim by Psyon, s.r.o., which has extensive experience in psychedelic-assisted (psylocibin......

Cardiac and Cardiovascular systems

  • 2024 - 2027
    • •
  • 29 443 tis. Kč
    • •
  • 12 682 tis. Kč
    • •
  • MŠMT
Projekt

Acute behavioral changes and acute and chronic toxicity of synthetic psychedelic drugs and their combinations in rats (NJ7636)

Examination of the effect of co-administration of MDMA with LSD or psilocin to rats on behaviour (open field, elevated plus maze, startle test) and concurent measuring the neurotransmitter levels in the brain of freely moving rats using microdialysis...

FL - Psychiatrie, sexuologie

  • 2003 - 2005
    • •
  • 6 510 tis. Kč
    • •
  • 5 996 tis. Kč
    • •
  • MZ
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