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5 397 (0,153s) •

Projekt

Chemistry of Fluorine-Containing butenolides (GA203/96/1057)

parts: The first part is concerning syntheses of 2-fluoro-2-butenolides (A,2(5H)-3-fluorofuranones) and 3-halogeno-2-fluoro-2-butenolides (B); both basic structures are also, and larger part is c...

CC - Organická chemie

  • 1996 - 1998
    • •
  • 1 184 tis. Kč
    • •
  • 1 066 tis. Kč
    • •
  • GA ČR
Projekt

Novel nucleosides and nucleotides derived from hetero-fused 7-deazapurines (GA16-00178S)

Novel types of hetero-fused 7-deazapurine bases (e.g. diverse isomers of thieno-, furo-, pyrido-, pyrrolo- or pyrazolopyrrolopyrimidines) will be designed and their synthesis will be developer based on either classical heterocyclizations, ph...

CC - Organická chemie

  • 2016 - 2018
    • •
  • 6 531 tis. Kč
    • •
  • 5 868 tis. Kč
    • •
  • GA ČR
Projekt

Butenolides with neuroprotective effect from plant-derived smoke and their synthetic derivatives (GA20-11571S)

Karrikins and 3,4,5-trimethylfuran-2(5H)-one (TMB) are butenolide structures identified in the smoke from burning vegetation that were found to be extremely potent seed germination regulators with effect also to the development of y...

Organic chemistry

  • 2020 - 2022
    • •
  • 6 310 tis. Kč
    • •
  • 4 786 tis. Kč
    • •
  • GA ČR
Projekt

Research and development of components for modern ultrasupercritical power plant 660 MW - new materials for presure parts. (FT-TA3/042)

Development and testing of production of new 9 - 12% -chromium steel with long-term creep resistance characterized by the value of R mT/600C/10 5h over 100 Mpa. Production and complex testing of the steel and also forget steam pipe for the m...

JE - Nejaderná energetika, spotřeba a užití energie

  • 2006 - 2010
    • •
  • 14 441 tis. Kč
    • •
  • 7 790 tis. Kč
    • •
  • MPO
Projekt

New cyclization reaction affording dinitrogen heterocycles (GA203/02/0306)

The subject of the project has been a new cyclization reaction affording dinitrogen heterocycles with trifluoromethyl group. In the cyclization, three components are involved: diamine, (methyl) 3,3,3-trifluoro-pyruvate and ketone or aldehyde. General...

CC - Organická chemie

  • 2002 - 2004
    • •
  • 2 280 tis. Kč
    • •
  • 1 050 tis. Kč
    • •
  • GA ČR
Projekt

Complexes of IL-2 and anti-IL-2 mAb with selective stimulatory activity for CD25+ T cells in cancer immunotherapy changing the paradigm (GA22-20548S)

Complexes of IL-2 and anti-IL-2 mAbs possess extremely high biological activity in vivo. Moreover, such IL-2 complexes have selective stimulatory activity for different IL-2 responsive cells depending on the clone ...

Oncology

  • 2022 - 2024
    • •
  • 8 330 tis. Kč
    • •
  • 8 330 tis. Kč
    • •
  • GA ČR
Projekt

Strong sustained IL-2 signal selectively targeted to CD25+ cells dramatically increases sensitivity to LPS-mediated mortality finding the mechanism (GA13-12885S)

It has been shown previously that complexing IL-2 with certain anti-IL-2 mAb enourmously increases activity of IL-2 in vivo. These immunocomplexes selectively stimulate different subsets of immune cells depending on clone ...

EC - Imunologie

  • 2013 - 2018
    • •
  • 11 872 tis. Kč
    • •
  • 11 872 tis. Kč
    • •
  • GA ČR
Projekt

IL-2 complexed with muteins of JES6-1 mAb having different affinity to IL-2 finding variant with most selective stimulation of Treg cells in vivo (GA18-12973S)

Complexes of IL-2 and anti-IL-2 mAb JES6-1 potently expand CD25+ cells, i.e to understanding the mechanism how these complexes interact with high affinity trimeric IL-2 receptor. JES6-1 mAb sterically blocks the interaction...

Immunology

  • 2018 - 2022
    • •
  • 4 804 tis. Kč
    • •
  • 4 762 tis. Kč
    • •
  • GA ČR
Projekt

*Modernization of the VS 2 ejection seat. (FT-TA3/046)

*Modernization of the VS 2 ejection seat....

JU - Aeronautika, aerodynamika, letadla

  • 2006 - 2008
    • •
  • 35 869 tis. Kč
    • •
  • 18 212 tis. Kč
    • •
  • MPO
Projekt

Study of anion processes relevant for astrophysics (7AMB14AT023)

The primary objective of the project on the czech side is the measurement of the temperature dependence of the rate coefficients of O - + H 2 -> H 2 O + e - O - + H 2 of the isotopicexchange H 2 /D 2 . The...

CF - Fyzikální chemie a teoretická chemie

  • 2014 - 2015
    • •
  • 200 tis. Kč
    • •
  • 200 tis. Kč
    • •
  • MŠMT
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