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Výsledek výzkumu

Warfarin-related nephropathy

Warfarin-related nephropathy is a relatively new nosological entity. It is characterized by an acute kidney injury due to over-warfarinizationwithin a week of its detection. It more frequently occurs in chronic kidney disea...

Cardiac and Cardiovascular systems

  • 2018
  • JSC
  • Odkaz
Výsledek výzkumu

The issue of anticoagulation from a nephrologist's perspective

called warfarin-related nephropathy (WRN), it is currently referred to as anticoagulant-related nephropathy. The aim of the article is to provide a comprehensive (not only renal) complications of warf...

Urology and nephrology

  • 2019
  • JSC
  • Odkaz
Výsledek výzkumu

Bioptically Proven "Anticoagulation-Related Nephropathy" Induced by Dual Antiplatelet Therapy

Anticoagulation-related nephropathy (ARN) is a significant and underdiagnosed complication in patients who receive anticoagulation therapy. It is characterized by acute kidney injury in the setting of excessive anticoagulation defin...

Urology and nephrology

  • 2018
  • Jimp
  • Odkaz
Výsledek výzkumu

New anticoagulants from the nephrologist's point of view

. vascular calcifications, calciphylaxis, and warfarin-induced nephropathy (quite gold standard - i.e. coumarins (the most common of which being warfarin in our time, it increases the risk of bleeding. While warfarin

FE - Ostatní obory vnitřního lékařství

  • 2016
  • Jx
  • Odkaz
Výsledek výzkumu

The Bleeding Risk during Warfarin Therapy Is Associated with the Number of Variant Alleles of CYP2C9 and VKORC1 Genes

variant allele count of CYP2C9 and VKORC1 genes on bleeding related to warfarinWarfarin is commonly used for the treatment and prevention of arterial and venous thromboembolism but its use is hindered by the risk of bleedi...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2013
  • Jx
  • Odkaz
Výsledek výzkumu

Carbonyl reduction of warfarin: Identification and characterization of human warfarin reductases

Warfarin is a widely used anticoagulant and, unfortunately, is a drug factors, including the metabolism of warfarin via CYP450, have been reported to affect the safety and efficacy of warfarin therapy, the wide variance in ...

FR - Farmakologie a lékárnická chemie

  • 2016
  • Jx
  • Odkaz
Výsledek výzkumu

Pharmacogenetics of warfarin and anticoagulation therapy

Pharmacogenetics of warfarin is a perspective technique able to predict daily dose of warfarin even before the initiation of therapy and to assess a risk of bleeding complications....

EB - Genetika a molekulární biologie

  • 2011
  • Jx
Výsledek výzkumu

New high-performance liquid chromatography method for the determination of (R)-warfarin and (S)-warfarin using chiral separation on a glycopeptide-based stationary phase

In the paper, we describe novel HPLC method for the determination of (R)-warfarin and (S)-warfarin using chiral separation on a glycopeptide-based stationary phase in cell culture media and lysates....

Pharmacology and pharmacy

  • 2009
  • Jimp
Výsledek výzkumu

Accuracy of pharmacogenetic algorithms in predicting warfarin daily dose

Introduction: Warfarin is used in a wide range of doses and requires frequent of warfarin dose is determined by the individual genotype and CYP2C9 and VKORC1 gene polymorphisms.Pharmacogenetic algorithms could be used to predict the...

FH - Neurologie, neurochirurgie, neurovědy

  • 2013
  • Jx
  • Odkaz
Výsledek výzkumu

Effect of model flavonolignan on metabolism of warfarin in rats in vitro

Warfarin, a known anticoagulant, was initially marketed as a rodenticide. Warfarin was found to be effective and relatively safe in prevention of thrombosis to metabolize warfarin. Hydroxylation of warfarin in rats...

CE - Biochemie

  • 2011
  • Jx
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