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Výsledek výzkumu

Shoot senescence in herbaceous perennials of the temperate zone: Identifying drivers of senescence pace and shape

and discard them before the advent of winter. The senescence of above-ground structures. Here we address patterns and drivers of the shoot senescence of perennial spring ephemeroids to species senescing in late autumn, in ...

Ecology

  • 2022
  • Jimp
  • Odkaz
Výsledek výzkumu

Premature senescence and COPD

Senescence is a natural process, but premature senescence is a disorder, the cause of which are a matter of research. Understanding senescence can improve the prevention and offers a chance for specific treatment and prolon...

FC - Pneumologie

  • 2016
  • Jx
Výsledek výzkumu

Senescence-Associated miRNAs and Their Role in Pancreatic Cancer

Replicative senescence is irreversible cell proliferation arrest for somatic cells which can be circumvented in cancers. Cellular senescence is a process, which. On the other hand, cellular secretion caused by senescence ca...

Pathology

  • 2022
  • Jimp
  • Odkaz
Výsledek výzkumu

The role of cellular senescence in neurodegenerative diseases

Increasing evidence has revealed that cellular senescence drives NDs, including Alzheimer’s disease (AD) and Parkinson’sdisease. Different senescent cell populations secrete senescence-associated secretory phenotypes (SASP)...

Pharmacology and pharmacy

  • 2024
  • Jimp
  • Odkaz
Výsledek výzkumu

Macrophages, Nitric Oxide and microRNAs Are Associated with DNA Damage Response Pathway and Senescence in Inflammatory Bowel Disease

Background: Cellular senescence can be a functional barrier to carcinogenesis. We hypothesized that inflammation modulates carcinogenesis through senescence and DNA damage response (DDR). We examined the association between sene...

FD - Onkologie a hematologie

  • 2012
  • Jx
  • Odkaz
Výsledek výzkumu

Selective elimination of senescent cells by mitochondrial targeting is regulated by ANT2

Cellular senescence is a form of cell cycle arrest that limits to subsequently eliminate senescent cells from the organism may lead to tissue damage anticancer agents, kills cancer cells without inducing senescence in vitro...

Biochemistry and molecular biology

  • 2019
  • Jimp
  • Odkaz
Výsledek výzkumu

Synergism of BCL-2 family inhibitors facilitates selective elimination of senescent cells

Accumulation of senescent cells in tissues with advancing age participates in the pathogenesis of several human age-associated diseases. Specific senescent secretome, the resistance of senescent cells to apoptotic stimuli, ...

Cell biology

  • 2022
  • Jimp
  • Odkaz
Výsledek výzkumu

Mycotoxins and cellular senescence: the impact of oxidative stress, hypoxia, and immunosuppression

cellular senescence, which are involved in their immunomodulatory effects. Mycotoxins upregulate the expression of senescence markers γ-H2AX, senescence-associated β-galactosidase, p53, p16, and senescence-associa...

Toxicology

  • 2023
  • Jimp
  • Odkaz
Výsledek výzkumu

c-Jun N-terminal kinase signaling in cellular senescence

Cellular senescence leads to decreased tissue regeneration and inflammation, the mechanisms of cellular senescence are not fully understood. Emerging evidence has of cellular senescence. JNK can downregulate hypoxia inducib...

Medicinal chemistry

  • 2023
  • Jimp
  • Odkaz
Výsledek výzkumu

Interaction between embryonic graft tissue and senescent host brain

Embryonic graft tissue, senescent rats...

FH - Neurologie, neurochirurgie, neurovědy

  • 2001
  • Jx
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