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6 677 (0,116s) •

Projekt

Developemnt of technological solution concept of a new nuclear unit fulfilling Generation III reguirements based on reactor WWER 1000 (2A-1TP1/139)

Development of technological solution concept of a new nuclear unit fulfilling to proposeefficient design modifications, which could significantly improve safety and technical modifications focused on nuclare safety improve...

JF - Jaderná energetika

  • 2006 - 2010
    • •
  • 169 126 tis. Kč
    • •
  • 114 594 tis. Kč
    • •
  • MPO
Projekt

Control of stress and interferon regulated gene expression by transcription factors, histone modification and nuclear compartmentalization (GEDYN/04/E002)

Interferon and cellular stresses are well established factors known to stimulate gene transcription. Their impact is mediated by distinct signalling pathways and MSK kinases on histone modification, chromatin structure and assembly ...

EA - Morfologické obory a cytologie

  • 2005 - 2007
    • •
  • 4 713 tis. Kč
    • •
  • 4 713 tis. Kč
    • •
  • GA ČR
Projekt

Interactions between nuclear and nucleolar proteins controlling cell proliferation and apoptosis effectors during leukemogenesis and therapy of leukemias. (NS9637)

Study of interactions between nuclear and nucleolar factors controlling cell proliferation and effectors of programmed cell death. Modifications and translocations during leukemogenesis and drug induced apoptosis in normal ...

FD - Onkologie a hematologie

  • 2008 - 2011
    • •
  • 7 084 tis. Kč
    • •
  • 7 008 tis. Kč
    • •
  • MZ
Projekt

Methodology of human factor assessment in operation of nuclear installations (JB200552004)

Human factor has a dominant influence on safety in operation of nuclear. The experience from the regulatory bodies involved in human factor analyses worldwide factor analyses and analyses of organizational fact...

JF - Jaderná energetika

  • 2005 - 2005
    • •
  • 3 000 tis. Kč
    • •
  • 1 500 tis. Kč
    • •
  • SÚJB
Projekt

Methods and tools for evaluation and increase of reliability of human factor in the operational of nuclear instalation. (1H-PK/21)

Design and validation of the methodology for reliability evaluation of the human factor in the operation of nuclear power plants. Then, base on the methodology andincreasing of the human factor reliability, i.e. decreasing ...

AQ - Bezpečnost a ochrana zdraví, člověk – stroj

  • 2004 - 2008
    • •
  • 50 291 tis. Kč
    • •
  • 30 054 tis. Kč
    • •
  • MPO
Projekt

Novel mechanisms of CYP3A4 enzyme regulation based on posttranslational modification of nuclear receptors - implications for pharmacotherapy (GAP303/12/0472)

CYP3A4 enzyme is the most important enzyme of drug/xenobiotic biotransformation, which metabolizes almost 50% of commonly used drugs. Nuclear receptors (NRs important ligand/xenobiotic-activated nuclear receptors responsible for bot...

FR - Farmakologie a lékárnická chemie

  • 2012 - 2016
    • •
  • 7 548 tis. Kč
    • •
  • 7 548 tis. Kč
    • •
  • GA ČR
Projekt

Participation and the transfer of results in the OECD _FIRE project (LA 196)

Analysis of the risks of the fire on nuclear facility, prevention of fire events, the evaluation of main factors...

BG - Jaderná, atomová a molekulová fyzika, urychlovače

  • 2003 - 2005
    • •
  • 3 230 tis. Kč
    • •
  • 1 615 tis. Kč
    • •
  • MŠMT
Projekt

Impact of radiation on distinctive physical properties of advanced materials for nuclear facilities (GA14-12449S)

The long-term reliability of construction materials operating in nuclear accelerators and construction steels for nuclear reactors. Structural transformations (amorphous to nanocrystalline) and modifications imposed by ther...

BM - Fyzika pevných látek a magnetismus

  • 2014 - 2016
    • •
  • 12 769 tis. Kč
    • •
  • 12 769 tis. Kč
    • •
  • GA ČR
Projekt

Postranslational modifications of histones after cell treatment by inhibitors of histone deacetylases and during induction of cell differentiation (GA204/06/0978)

Postranslational modifications of histone tails represent an important epigenetic factors playing specific role in the regulation of many cellular functions. Selected epigenetic histone modifications together with variants ...

EB - Genetika a molekulární biologie

  • 2006 - 2008
    • •
  • 1 878 tis. Kč
    • •
  • 1 878 tis. Kč
    • •
  • GA ČR
Projekt

Functions of nuclear myosin in gene expression (GA204/07/1592)

In 1997, we identified 120 kDa nuclear protein as a unique myosin IC form (NMI polymerases I and II, and described that NMI binds to TIFIA transcription factor of RNA transcription, Aim 2: Identification of NMI functions in transcri...

EB - Genetika a molekulární biologie

  • 2007 - 2009
    • •
  • 5 701 tis. Kč
    • •
  • 5 701 tis. Kč
    • •
  • GA ČR
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