Filtry
Structural characterization of replication of Staphylococcus aureus phage in vivo (GA18-17810S)
infections is preventing approval of human phage therapy. We propose to study the infection cycle of potential phage therapy agent, phage 812K1-420, in vivo in S. aureus of the phage and allow fu...
Virology
- 2018 - 2020 •
- 10 104 tis. Kč •
- 10 104 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2018 - 31. 12. 2020
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Structural studies of potential phage-therapy agent, Staphylococcus aureus phage 812K1-420 (GJ15-21631Y)
and weakened immune systems. Phages can be used to treat pathogenic bacteria that are resistant to antibiotics. However, no phage therapies are currently authorized in the West. Molecular-level description of the phage...
BO - Biofyzika
- 2015 - 2019 •
- 8 304 tis. Kč •
- 8 304 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2015 - 25. 4. 2019
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Analysis of interactions between polyvalent Twort-like therapeutic phage and its host Staphylococcus aureus (GA18-13064S)
and host that is necessary for put the phage therapy into the practice. century. However, approval of bacteriophage therapy as a safe method requires detailed. These phages are the subject of intensive research, r...
Microbiology
- 2018 - 2022 •
- 7 793 tis. Kč •
- 7 052 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2018 - 31. 12. 2022
Uznané náklady
Podpora ze státního rozpočtu (90%)
Poskytovatel: Grantová agentura České republiky
Research of broad host-range mutants of staphylococcal bacteriophages (TA01010405)
The aim of the proposed project is development of a stable phage preparation containig as a effective compound the novel phage mutants with lytic activity towards mutants of the virulent phage 812 will be prepared by geneti...
EE - Mikrobiologie, virologie
- 2011 - 2015 •
- 10 297 tis. Kč •
- 7 764 tis. Kč •
- TA ČR
Řešení projektu: 1. 1. 2011 - 31. 12. 2015
Uznané náklady
Podpora ze státního rozpočtu (75%)
Poskytovatel: Technologická agentura ČR
Development of nanobiotechnology methods for monitoring of therapeutic staphylococcal bacteriophages in clinical samples (NU22-05-00042)
of clinical studies and the phage-bacteria interactions are intensively studied. Despite the high tolerability and efficacy of phage therapy, the implementation into the common. The effectivity of phage therap...
Biochemistry and molecular biology
- 2022 - 2025 •
- 8 885 tis. Kč •
- 8 885 tis. Kč •
- MZ
Řešení projektu: 1. 5. 2022 - 31. 12. 2025
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
Synergy of lytic bacteriophages and antibiotics in the therapy of topical infections of Staphylococcus aureus (NU21J-05-00035)
of new antibiotics. An alternative is the use of so-called phage therapy, i.e is much more rapid and less expensive. However, phage therapy remains an experimental to the use of phages or antibiotics alon...
Infectious Diseases
- 2021 - 2025 •
- 6 761 tis. Kč •
- 6 761 tis. Kč •
- MZ
Řešení projektu: 1. 5. 2021 - 31. 12. 2025
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
Integrated genome and proteome analysis of therapeutically important bacteriophages by combination of electrophoresis and mass spectrometry (GA203/03/0515)
infections. For a rational development of phage therapy, without the adverse effects of suitable phages and their genome/proteome structure must be found. To achieve this goal it is necessary to find new technologies for r...
CB - Analytická chemie, separace
- 2003 - 2005 •
- 7 442 tis. Kč •
- 3 890 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2003 - 1. 1. 2005
Uznané náklady
Podpora ze státního rozpočtu (52%)
Poskytovatel: Grantová agentura České republiky
Phage replication in bacterial biofilm (LL1906)
strategies for the development of antimicrobial compounds or phage therapy. We will use focused ion beam milling and cryo-electron tomography to analyze the effect of phage tissues. We propose to study the mechanisms that ...
Microbiology
- 2020 - 2022 •
- 35 299 tis. Kč •
- 35 299 tis. Kč •
- MŠMT
Řešení projektu: 1. 1. 2020 - 31. 12. 2022
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo školství, mládeže a tělovýchovy
The use of bacteriophages in the treatment of nosocomial infections associated with multidrug resistance or biofilm formation (NV16-29916A)
phages and their subtypes effective against multiresistant strains of staphylococci and pseudomonades. Phages will be biologically and genetically characterized, including complete of phages in cultures. The lytic effect o...
EE - Mikrobiologie, virologie
- 2016 - 2019 •
- 10 607 tis. Kč •
- 9 302 tis. Kč •
- MZ
Řešení projektu: 1. 4. 2016 - 31. 12. 2019
Uznané náklady
Podpora ze státního rozpočtu (88%)
Poskytovatel: Ministerstvo zdravotnictví
Implementation of a purification step into the manufacturing of bacteriophage lysates (FX01030019)
Aim of the project is to implement a new purification step into the manufacturing of phage lysates. Following steps will be carried out to reach the aim. Firstly, at least three new preselected purification methods will be optimized, will be...
Medical laboratory technology (including laboratory samples analysis; diagnostic technologies) (Biomaterials to be 2.9 [physical characteristics of living material as related to medical implants, devices, sensors])
- 2020 - 2023 •
- 16 734 tis. Kč •
- 7 760 tis. Kč •
- MPO
Řešení projektu: 1. 7. 2020 - 30. 6. 2023
Uznané náklady
Podpora ze státního rozpočtu (46%)
Poskytovatel: Ministerstvo průmyslu a obchodu
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