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Projekt

Alcohol and regulation of lipoprotein metabolism (NR7847)

The effect of alcohol consumption on expression of genes involved in regulation of lipoprotein metabolism (apolipoprotein A-I, ABC A1 transporter, lipoprotein lipase) will be studied in C57BL/6 mice. The role of genetic pre...

ED - Fyziologie

  • 2004 - 2006
    • •
  • 1 623 tis. Kč
    • •
  • 1 455 tis. Kč
    • •
  • MZ
Projekt

Gnetic control of antibody response. Mechanisms of low IgG production in C57BL mice. (GA310/95/0634)

EE - Mikrobiologie, virologie

  • 1995 - 1997
    • •
  • 1 516 tis. Kč
    • •
  • 1 516 tis. Kč
    • •
  • GA ČR
Projekt

Role of white adipose tissue in the thernogenic response (GA18-04483S)

of WAT metabolism by cold and genetically-determined resistance to obesity in mice (C57BL/6 vs. A/J), which could not be explained by thermogenesis mediated by uncoupling protein 1 (UCP1). Using these models, as well as

Endocrinology and metabolism (including diabetes, hormones)

  • 2018 - 2023
    • •
  • 6 516 tis. Kč
    • •
  • 5 979 tis. Kč
    • •
  • GA ČR
Projekt

Utilization of novel mouse strains for investigation of the NK cell regulatory role in development and therapy of cancer (GA14-10100S)

complex (NKC) exhibit high polymorphism between Balb/c (Th2-type) and C57BL/6 (Th1-type) mice. To elucidate the cellular and molecular mechanisms critical for tumor in transgenic Balb/c mice expressing Nkrp1cB6 ge...

FD - Onkologie a hematologie

  • 2014 - 2018
    • •
  • 10 006 tis. Kč
    • •
  • 10 006 tis. Kč
    • •
  • GA ČR
Projekt

Uncovering regulatory networks in novel mouse models by genetical genomics (GA301/07/1264)

As a first step in a genome-wide analysis of genetic regulatory processes, we propose to carry out a genetical genomics analysis of gene expression in mouse brain. Using a set of C57BL/6-ChrPWD mouse inter-species chromosome substit...

EB - Genetika a molekulární biologie

  • 2007 - 2009
    • •
  • 8 860 tis. Kč
    • •
  • 8 860 tis. Kč
    • •
  • GA ČR
Projekt

Obesity and insulin resistance the role of adipose tissue and the effect of omega-3 polyunsaturated fatty acids (GP303/03/P127)

of insulinresistance associated with dietary obesity. Both, C57BL/6J (B6) and AKR/J inbred strains of mice are prone to the development of obesity when fed a high fat diet. AKR/J mice, it was 3-fold lower in AKR/J mice...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2003 - 2005
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  • 750 tis. Kč
    • •
  • 750 tis. Kč
    • •
  • GA ČR
Projekt

Role of AMP-activated protein kinase in the modulation of lipid metabolism in white adipose tissue (KJB5011303)

in the adipose tissue of transgenic (aP2-Ucp1) mice. We will verify whether the energy status in control and transgenic aP2-Ucp1 mice and in adipocytes in vitro. The results......

EB - Genetika a molekulární biologie

  • 2003 - 2005
    • •
  • 1 823 tis. Kč
    • •
  • 1 049 tis. Kč
    • •
  • AV ČR
Projekt

Transplantation of the embryonic cerebellar tissue and stem cells into the cerebellum of Lurcher mutant and normal mice (OC10038)

of adult Lurcher mutant and normal wild type mice and to examine the effect of transplantation on motor function of Lurcher mice. Lurcher mutant mice will be used as a natural model of hereditary olivocerebellar degenerati...

FH - Neurologie, neurochirurgie, neurovědy

  • 2010 - 2011
    • •
  • 793 tis. Kč
    • •
  • 793 tis. Kč
    • •
  • MŠMT
Projekt

Reconstituting a minimum hybrid sterility genome (GA22-29928S)

model by sequential reconstitution of the C57BL/6 inbred strain genome so sterility. Our team possesses all congenic, transgenic and consomic mice, as well......

Genetics and heredity (medical genetics to be 3)

  • 2022 - 2023
    • •
  • 6 638 tis. Kč
    • •
  • 6 494 tis. Kč
    • •
  • GA ČR
Projekt

Strong epistatic control of development of leishmaniasis – identification of genes and mechanisms (GA16-22346S)

of the resistant strain O20 and 96% genes of the resistant strain C57BL/10, but is highly activation in non-infected and infected mice and determine the differences between non-infected mice of these strains and difference...

EB - Genetika a molekulární biologie

  • 2016 - 2020
    • •
  • 5 821 tis. Kč
    • •
  • 5 773 tis. Kč
    • •
  • GA ČR
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