Development of nanodiamond intracellular nanoprobes for oncogen transformation dynamics in living cells
Public support
Provider
Ministry of Education, Youth and Sports
Programme
—
Call for proposals
FP7-KBBE-2009-3
Main participants
—
Contest type
RP - Co-financing of EC programme
Contract ID
13595/2011 ? 321
Alternative language
Project name in Czech
Development of nanodiamond intracellular nanoprobes for oncogen transformation dynamics in living cells
Annotation in Czech
Dynamic information about biomolecular processes in living cells is important for fundamental understanding of cellular functions, which is one of the primary targets of molecular-cell biology with important applications to pharmacology. However for further progress in this field, and this specifically for monitoring genomic processes, there is immense need for developing sensing and detection techniquesthat can operate with sufficientsubmicroscopic resolution inside the living cells and bringing real-time information about local biomolecular interactions. The present proposal makes a further, large step towards integration of forefront nanotechnology, chemistry and molecular biology expertise with a common goal of studying intracellular processes in cells on nanoscale, which is the objective of this call. The aim of the DINAMO project is to develop the nanodiamond particle (NDP) non-invasive label free nanotechnology platform for real-time monitoring (1) of living cells modified by oncogenic impact,(2) of the kinetics of gene-assisted processes in the cell. Based on the development work of DINAMO, we propose to apply luminiscent and single spin detection techniques for real-time monitoring of biomoleuar processes in cells.
Scientific branches
R&D category
ZV - Basic research
CEP classification - main branch
FD - Oncology and haematology
CEP - secondary branch
EC - Immunology
CEP - another secondary branch
CF - Physical chemistry and theoretical chemistry
OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
10403 - Physical chemistry<br>30102 - Immunology<br>30204 - Oncology<br>30205 - Hematology
Completed project evaluation
Provider evaluation
U - Uspěl podle zadání (s publikovanými či patentovanými výsledky atd.)
Project results evaluation
Following the condition that the candidate of financial contribution was evaluated and afterwards selected by international provider in accordance with the rules of the program the Ministry of Education, Youth ans Sports does not realize the evaluation of project results. The project is evaluated only after its approval by an international provider.
Solution timeline
Realization period - beginning
Jan 1, 2011
Realization period - end
Apr 30, 2013
Project status
U - Finished project
Latest support payment
Mar 27, 2013
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP14-MSM-7E-U/01:1
Data delivery date
Jun 30, 2014
Finance
Total approved costs
3,081 thou. CZK
Public financial support
3,081 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK