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7E11026

Development of nanodiamond intracellular nanoprobes for oncogen transformation dynamics in living cells

Public support

  • Provider

    Ministry of Education, Youth and Sports

  • Programme

  • Call for proposals

    FP7-KBBE-2009-3

  • Main participants

  • Contest type

    RP - Co-financing of EC programme

  • Contract ID

    13595/2011 ? 321

Alternative language

  • Project name in Czech

    Development of nanodiamond intracellular nanoprobes for oncogen transformation dynamics in living cells

  • Annotation in Czech

    Dynamic information about biomolecular processes in living cells is important for fundamental understanding of cellular functions, which is one of the primary targets of molecular-cell biology with important applications to pharmacology. However for further progress in this field, and this specifically for monitoring genomic processes, there is immense need for developing sensing and detection techniquesthat can operate with sufficientsubmicroscopic resolution inside the living cells and bringing real-time information about local biomolecular interactions. The present proposal makes a further, large step towards integration of forefront nanotechnology, chemistry and molecular biology expertise with a common goal of studying intracellular processes in cells on nanoscale, which is the objective of this call. The aim of the DINAMO project is to develop the nanodiamond particle (NDP) non-invasive label free nanotechnology platform for real-time monitoring (1) of living cells modified by oncogenic impact,(2) of the kinetics of gene-assisted processes in the cell. Based on the development work of DINAMO, we propose to apply luminiscent and single spin detection techniques for real-time monitoring of biomoleuar processes in cells.

Scientific branches

  • R&D category

    ZV - Basic research

  • CEP classification - main branch

    FD - Oncology and haematology

  • CEP - secondary branch

    EC - Immunology

  • CEP - another secondary branch

    CF - Physical chemistry and theoretical chemistry

  • OECD FORD - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)

    10403 - Physical chemistry<br>30102 - Immunology<br>30204 - Oncology<br>30205 - Hematology

Completed project evaluation

  • Provider evaluation

    U - Uspěl podle zadání (s publikovanými či patentovanými výsledky atd.)

  • Project results evaluation

    Following the condition that the candidate of financial contribution was evaluated and afterwards selected by international provider in accordance with the rules of the program the Ministry of Education, Youth ans Sports does not realize the evaluation of project results. The project is evaluated only after its approval by an international provider.

Solution timeline

  • Realization period - beginning

    Jan 1, 2011

  • Realization period - end

    Apr 30, 2013

  • Project status

    U - Finished project

  • Latest support payment

    Mar 27, 2013

Data delivery to CEP

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

  • Data delivery code

    CEP14-MSM-7E-U/01:1

  • Data delivery date

    Jun 30, 2014

Finance

  • Total approved costs

    3,081 thou. CZK

  • Public financial support

    3,081 thou. CZK

  • Other public sources

    0 thou. CZK

  • Non public and foreign sources

    0 thou. CZK