Mitochondrial genome and transcriptome of euglenozoans: in search for unique and general trends of organellar nucleic acids management
Public support
Provider
Czech Science Foundation
Programme
Standard projects
Call for proposals
SGA0202600001
Main participants
Biologické centrum AV ČR, v. v. i.
Contest type
VS - Public tender
Contract ID
26-20659S
Alternative language
Project name in Czech
Mitochondrial genome and transcriptome of euglenozoans: in search for unique and general trends of organellar nucleic acids management
Annotation in Czech
Parasitic kinetoplastid and free-living diplonemid protists evolved the most unusual mitochondrial (kinetoplast) genomes documented so far. In the model flagellate Trypanosoma brucei, we will dissect the machinery responsible for its replication, maintenance, transcription and extensive RNA editing. For this, we will apply recent extensive MitoTag-based knowledge of the kinetoplast protein components, new visualization tools such as expansion and atomic force microscopy, and a novel computational framework T-Aligner that we have designed. We will also analyze the biggest known organellar DNA of Namystynia, with its hallucinated sequences of extreme mechanics, and map the deletions in mitochondrial genome of economically important fish-infecting trypanosomes. Our preliminary data point to the existence of a yet undescribed protein import pathway in the T. brucei mitochondrion, which we aim to fully characterize. Our aim is to present a holistic model of the kinetoplast, a defining structure of trypanosomatids, as well as the evolutionary framework that led to its emergence.
Scientific branches
R&D category
ZV - Basic research
OECD FORD - main branch
10601 - Cell biology
OECD FORD - secondary branch
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OECD FORD - another secondary branch
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CEP - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
EA - Morphology and cytology
Solution timeline
Realization period - beginning
Jan 1, 2026
Realization period - end
Dec 31, 2028
Project status
Z - Beginning multi-year project
Latest support payment
—
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP26-GA0-GA-R
Data delivery date
May 26, 2026
Finance
Total approved costs
11,529 thou. CZK
Public financial support
11,529 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK