Dry powder composite systems of stimuli-responsive polymers and 2D materials for pulmonary drug delivery
Public support
Provider
Czech Science Foundation
Programme
Standard projects
Call for proposals
SGA0202600001
Main participants
Ústav makromolekulární chemie AV ČR, v. v. i.
Contest type
VS - Public tender
Contract ID
26-21213S
Alternative language
Project name in Czech
Dry powder composite systems of stimuli-responsive polymers and 2D materials for pulmonary drug delivery
Annotation in Czech
Pulmonary diseases remain a leading global health burden, among the top 10 causes of death and contributing significantly to disability-adjusted life years. While treatments exist, their liquid formulations have limited shelf life and require refrigerated transport for stability, restricting access in remote regions. To address this challenge, we propose the development of Powder2Deliver, a scalable platform for redispersible solid formulations using drug-loaded polymer/hexagonal boron nitride (hBN) hybrid nanocomposites. This innovative approach combines microfluidic self-assembly with one-step spray-drying for efficient pulmonary drug delivery. The platform will design drug-loaded powders (e.g., core-shell, capsules, matrix spheres) responsive to inflammation and cancer (via ROS and pH triggers), optimized for stability and efficacy. This multidisciplinary project aims to create versatile long-lasting redispersible drug powders with tailored structures and broad compatibility.
Scientific branches
R&D category
ZV - Basic research
OECD FORD - main branch
10404 - Polymer science
OECD FORD - secondary branch
10402 - Inorganic and nuclear chemistry
OECD FORD - another secondary branch
20501 - Materials engineering
CEP - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
CA - Inorganic chemistry<br>CD - Macromolecular chemistry<br>CH - Nuclear and quantum chemistry, photo chemistry<br>JG - Metallurgy, metal materials<br>JP - Industrial processes and processing
Solution timeline
Realization period - beginning
Jan 1, 2026
Realization period - end
Dec 31, 2028
Project status
Z - Beginning multi-year project
Latest support payment
—
Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP26-GA0-GA-R
Data delivery date
May 19, 2026
Finance
Total approved costs
8,952 thou. CZK
Public financial support
8,952 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK