Two for the Price of One: Illuminating the Dual Role of Paralogous Exocyst Subunits in Plants
Public support
Provider
Czech Science Foundation
Programme
Standard projects
Call for proposals
SGA0202600001
Main participants
Ústav experimentální botaniky AV ČR, v. v. i.
Contest type
VS - Public tender
Contract ID
26-23510S
Alternative language
Project name in Czech
Two for the Price of One: Illuminating the Dual Role of Paralogous Exocyst Subunits in Plants
Annotation in Czech
Exocytosis, the final step of the secretory pathway, is spatiotemporally controlled by the exocyst, an evolutionarily conserved protein complex. Uniquely in plants, several exocyst subunits diversified into multiple paralogs. We recently discovered that sporophyte- and pollen-dominant isoforms of these subunits can exhibit non-redundant dual functions, making the exocyst an exciting model that bridges cell biology and evolution. We hypothesise that this adaptive diversification of exocyst subunits introduces new layers of regulatory control over vesicle trafficking. Focusing on paralogous EXO84 and SEC15 isoforms that display dual roles, we aim to define how their structural and biochemical properties confer specificity in both sporophyte and pollen. By employing multifaceted methods, we will dissect exocyst architecture in different tissues, clarify isoform relationships, and identify novel interactors that govern exocyst function. This research will enrich our understanding of membrane traffic evolution in plants and beyond.
Scientific branches
R&D category
ZV - Basic research
OECD FORD - main branch
10611 - Plant sciences, botany
OECD FORD - secondary branch
10601 - Cell biology
OECD FORD - another secondary branch
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CEP - equivalent branches <br>(according to the <a href="http://www.vyzkum.cz/storage/att/E6EF7938F0E854BAE520AC119FB22E8D/Prevodnik_oboru_Frascati.pdf">converter</a>)
EA - Morphology and cytology<br>EF - Botany
Solution timeline
Realization period - beginning
Jan 1, 2026
Realization period - end
Dec 31, 2028
Project status
Z - Beginning multi-year project
Latest support payment
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Data delivery to CEP
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data delivery code
CEP26-GA0-GA-R
Data delivery date
Apr 30, 2026
Finance
Total approved costs
7,988 thou. CZK
Public financial support
7,988 thou. CZK
Other public sources
0 thou. CZK
Non public and foreign sources
0 thou. CZK