Dynamic changes of B-cell compartments in kidney transplantation: lack of transitional B cells is associated with allograft rejection

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F16%3A00059999" target="_blank" >RIV/00023001:_____/16:00059999 - isvavai.cz</a>

Result on the web

<a href="http://onlinelibrary.wiley.com/doi/10.1111/tri.12751/epdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/tri.12751/epdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/tri.12751" target="_blank" >10.1111/tri.12751</a>

Result language

angličtina

Original language name

Dynamic changes of B-cell compartments in kidney transplantation: lack of transitional B cells is associated with allograft rejection

Original language description

B cells play an important role in the immune responses which affect the outcomes of kidney allografts. Dynamic changes of B-cell compartments in clinical kidney transplantation are still poorly understood. B-cell subsets were prospectively monitored using flow cytometry for 1 year in 98 kidney transplant recipients. Data were correlated with immunosuppression and clinical outcomes. An increase in the total population of B lymphocytes was observed during the first week after transplantation. The level of IgM(high)CD38(high)CD24(high) transitional B cells reduced significantly up until the third month, with partial repopulation in the first year. Lower numbers of transitional B cells in the third month were associated with higher risk of graft rejection. IgM(+)IgD(+)CD27(-) naive B cells did not change within follow-up. IgM(+)CD27(+) nonswitched memory B cells and IgM(-)CD27(+) switched memory B cells increased on post-operative day 7. IgM(-)CD38(high)CD27(high) plasmablasts showed similar kinetics during the first post-transplant year, similar to transitional B cells. In conclusion, sensitized kidney transplant recipients as well as those with either acute or chronic rejection within the first post-transplant year exhibited lower levels of transitional B cells. Therefore, these data further support the hypothesis that transitional B cells have a protective role in kidney transplantation.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FJ - Surgery including transplantology

OECD FORD branch

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Project

<a href="/en/project/NT14102" target="_blank" >NT14102: A role of B lymphocytes in immune reactions after kidney transplantation</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Transplant international

ISSN

0934-0874

e-ISSN

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Volume of the periodical

29

Issue of the periodical within the volume

5

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

540-548

UT code for WoS article

000375064100004

EID of the result in the Scopus database

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