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Proteome changes in leukemic cells induced by photodynamic treatment.

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F04%3AI0000076" target="_blank" >RIV/00023736:_____/04:I0000076 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Proteome changes in leukemic cells induced by photodynamic treatment.

  • Original language description

    By means of two-dimensional electrophoresis the effects of photodynamic therapy, ALA-PDT, were studied on leukemia cell lines HL60 and K562. ALA-PDT affected several cellular pathways in HL60 cells including glycolytic and oxidative phosphorylation functions as well as apoptosis. In K562 cells the apoptosis was trigered which did not proceed to the executive phase presumably due to the high level of molecular chaperones in this cell line.

  • Czech name

    Změny proteomů v leukemických buňkách vyvolané fotodynamickou terapií

  • Czech description

    Metodou dvojrozměrné elektroforézy byly studovány účinky fotodynamické terapie, ALA-PDT, na leukemické buněčné linie HL60 a K562. U buněk HL60 bylo ALA-PDT ovlivněno několik buněčných drah včetně glykolytických funkcí, oxidativní fosforylace a apoptozy.U buněk K562 byla ALA-PDT navozena apoptoza, jež však neproběhla do exekuční fáze, patrně v důsledku vysoké hladiny molekulárních chaperonů v této buněčné linii.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FD - Oncology and haematology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/NL7681" target="_blank" >NL7681: Exprimental pharmacotherapy of chronic myelogenous leukemia the proteomic approach</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2004

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Hematology Journal

  • ISSN

    1466-4860

  • e-ISSN

  • Volume of the periodical

    5

  • Issue of the periodical within the volume

    S2

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    2

  • Pages from-to

    "S243"-"S244"

  • UT code for WoS article

  • EID of the result in the Scopus database