Variations in c-Myc and p21WAF1 expression protect normal peripheral blood lymphocytes against BimEL-mediated cell death

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F09%3A00008278" target="_blank" >RIV/00023736:_____/09:00008278 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Variations in c-Myc and p21WAF1 expression protect normal peripheral blood lymphocytes against BimEL-mediated cell death

Original language description

We have examined the effect of Suberoylanilide hydroxamic acid (SAHA) on the viability of normal peripheral blood lymphocytes (PBL) in vitro and the effect of this agent on the expression of twenty apoptosis-related genes. Data suggest that PBL markedlyresisted for about 24 hours the destructive activity of the agent, but eventually 60pct of cells treated with SAHA died within 72 hours. We suggest that variations in c-myc and p21(WAF1) expression may decelerate the apoptosis in the early period and increase the resistance of resting PBL against SAHA

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

<a href="/en/project/GA301%2F09%2F1026" target="_blank" >GA301/09/1026: Proteomic analysis of suberoylanilide hydroxamic acid (SAHA) effects on human leukemic cells</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cell Biochemistry and Function

ISSN

0263-6484

e-ISSN

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Volume of the periodical

27

Issue of the periodical within the volume

3

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

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UT code for WoS article

000265312500008

EID of the result in the Scopus database

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