New platinum (IV) complex with adamantylamine ligand as a promising anti-cancer drug: Comparison of in vitro cytotoxic potential towards A2780/cisR cisplatin-resistant cell line within homologous series of platinum (IV) complexes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F04%3A00012445" target="_blank" >RIV/00027162:_____/04:00012445 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/04:00104665
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
New platinum (IV) complex with adamantylamine ligand as a promising anti-cancer drug: Comparison of in vitro cytotoxic potential towards A2780/cisR cisplatin-resistant cell line within homologous series of platinum (IV) complexes
Original language description
Platinum(IV) complexes with bulky hydrophobic ligands (LA-12 and LA-15) demonstrated about one order higher velocity constant for pseudo-first-order reaction with glutathione in comparison to cisplatin, LA-4 and LA-2, whose velocity constants were closeto those measured for cisplatin and related platinum(II) complexes. Cytotoxicities of LA-12 and LA-15 towards cisplatin-resistant epithelial carcinoma A2780/cisR were superior to cisplatin, LA-4 and LA-2 in both 24- and 72-h continuous exposure (MTT tests). Rapid induction of apoptosis in the treated cancer cell lines and no cisplatin cross-resistance were found for LA-12, which is a candidate for clinical testing.
Czech name
Nový komplex platiny (IV) s adamantylaminovým ligandem jako nadějná protinádorová látka: srovnání in vitro cytotoxického potenciálu na nádorové linii A2780/cisR v rámci homologní serie Pt(IV) complexů
Czech description
Pt(IV) komplexy s objemnými hydrofobními ligandy (LA-12 a LA-15) vykazovaly o jeden řád vyšší rychlostní konstanty pseudo-prvního řádu při reakci s glutathionem ve srovnání s cisplatinou a dalšími Pt(II) komplexy. Cytotoxicita LA-12 a LA-15 vůči cisplatin-resistentní linii A2780/cisR byla vyšší než u LA-4 a LA-2 jak při 24h tak 72 h expozici (MTT test). Rychlá indukce apoptózy a žádná zkřížená resistence vůči cisplatině dávají komplexu LA-12 naději v klinickém testování.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2004
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Anti-cancer Drugs
ISSN
0959-4973
e-ISSN
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Volume of the periodical
15
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
537-543
UT code for WoS article
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EID of the result in the Scopus database
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