True Nondisjunction of Whole Bivalents in Oocytes with Attachment and Congression Defects
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F17%3AN0000100" target="_blank" >RIV/00027162:_____/17:N0000100 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/17:00094711
Result on the web
<a href="https://www.karger.com/Article/Abstract/458513" target="_blank" >https://www.karger.com/Article/Abstract/458513</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1159/000458513" target="_blank" >10.1159/000458513</a>
Alternative languages
Result language
angličtina
Original language name
True Nondisjunction of Whole Bivalents in Oocytes with Attachment and Congression Defects
Original language description
Chromosome segregation in mammalian oocytes is prone to errors causing aneuploidy with consequences such as precocious termination of development or severe developmental disorders. Aneuploidy also represents a serious problem in procedures utilizing mammalian gametes and early embryos in vitro. In our study, we focused on congression defects during meiosis I and observed whole nondisjoined bivalents in meiosis II as a direct consequence, together with a substantially delayed first polar body extrusion. We also show that the congression defects are accompanied by less stable attachments of the kinetochores. Our results describe a process by which congression defects directly contribute to aneuploidy
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10604 - Reproductive biology (medical aspects to be 3)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cytogenetic and Genome Research
ISSN
1424-8581
e-ISSN
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Volume of the periodical
151
Issue of the periodical within the volume
1
Country of publishing house
CH - SWITZERLAND
Number of pages
8
Pages from-to
10-17
UT code for WoS article
000399694600003
EID of the result in the Scopus database
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