Immune response to sublingualy delievered recombinant antigenes in experimental mice

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00027162%3A_____%2F18%3AN0000087" target="_blank" >RIV/00027162:_____/18:N0000087 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Immune response to sublingualy delievered recombinant antigenes in experimental mice
Original language description
The oromucosal route of administration is a route for vaccine delivery alternative to parenteral invasive routes such as intramuscular, subcutaneous or intradermal ones. It offers posibility to induce both mucosal and systemic responses without potential to induce mucosal tolerance. Sublingual vaccination does not require strictly sterile vaccine application conditions, and, in contrast to other mucosally effective intranasal route, it does not elicit rare but severe toxic side effects caused by penetration of antigen and adjuvants across olfactory epithelium, leading to damage to olfactory nerves or Bell´s palsy. Using experimental mice model, several recombinant proteins and inactive virus vaccine were tested for elicitation of mucosal and systemic responses after sublingual dropwise, sublingual patch, and parenteral administrations. Sublingual patches immunization induces both mucosal and systemic responses of various intensities dependent on antigen nature and adjuvant usage. No side effects were observed in any experimental animals.
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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