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Immune response to sublingually delivered recombinant antigens in experimental mice

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F18%3A73591345" target="_blank" >RIV/61989592:15110/18:73591345 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Immune response to sublingually delivered recombinant antigens in experimental mice

  • Original language description

    The oromucosal route of administration is a route for vaccine delivery alternative to parenteral invasive routes such as intramuscular, subcutaneous or intradermal ones. It offers possibility to induce both mucosal and systemic responses without potential to induce mucosal tolerance. Sublingual vaccination does not require strictly sterile vaccine application conditions, and, in contrast to other mucosally effective intranasal route, it does not elicit rare but severe toxic side effects caused by penetration of antigen and adjuvants across olfactory epithelium, leading to damage to olfactory nerves or Bell´s palsy.Using experimental mice model, several recombinant proteins and inactive virus vaccine were tested for elicitation of mucosal and systemic responses after sublingual drop wise, sublingual patch, and parenteral administrations.Sublingual patches immunization induces both mucosal and systemic responses of various intensities dependent on antigen nature and adjuvant usage. No side effects were observed in any experimental animals.

  • Czech name

  • Czech description

Classification

  • Type

    D - Article in proceedings

  • CEP classification

  • OECD FORD branch

    30102 - Immunology

Result continuities

  • Project

    <a href="/en/project/EF16_025%2F0007397" target="_blank" >EF16_025/0007397: Recombinant Biotechnology and Immunotherapy Centre</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Article name in the collection

    11th International Conference Drug Delivery Systems Nanotechnology for Healthcare: Progress in Recombinant Vaccines, Molecular Adjuvants, Modern Drug Delivery Systems and Cell Therapy

  • ISBN

    978-80-907074-6-7

  • ISSN

  • e-ISSN

    neuvedeno

  • Number of pages

    11

  • Pages from-to

    71-81

  • Publisher name

    nakladatelství Machovský

  • Place of publication

    Olomouc

  • Event location

    Telč

  • Event date

    Jun 5, 2018

  • Type of event by nationality

    WRD - Celosvětová akce

  • UT code for WoS article