Epithelial basement membrane thickening is related to TGF-Beta 1 expression in children with chronic respiratory diseases
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F14%3A10293145" target="_blank" >RIV/00064203:_____/14:10293145 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/14:10293145
Result on the web
<a href="http://dx.doi.org/10.1111/pai.12275" target="_blank" >http://dx.doi.org/10.1111/pai.12275</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/pai.12275" target="_blank" >10.1111/pai.12275</a>
Alternative languages
Result language
angličtina
Original language name
Epithelial basement membrane thickening is related to TGF-Beta 1 expression in children with chronic respiratory diseases
Original language description
BackgroundThe complex structural changes of bronchial mucosa, known as remodelling, have been considered unique and typical for asthma. However, similar changes were recently found in other chronic respiratory diseases. The aim of this study was to compare basement membrane (BM) thickness and the number of transforming growth factor beta 1 (TGF-1) positive epithelial cells in children with asthma, cystic fibrosis (CF), primary ciliary dyskinesia (PCD) and healthy controls. MethodsA total of 58 children(11.13.9yr, 55% males) were enrolled in this cross-sectional study. Endobronchial biopsy was performed in 27 children with asthma, 12 with CF, 12 with PCD and in 7 control patients. We studied the samples using light microscopy to assess BM width, the number of TGF-1 positive epithelial cells and their correlation. ResultsWe found increased BM thickness (6.65 +/- 1.22m vs. 2.93 +/- 0.75m, p<0.01) and a higher number of TGF-1 positive epithelial cells (61.39 +/- 19.03 vs. 21.57 +/- 12.58,
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FG - Paediatrics
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NT11444" target="_blank" >NT11444: Early symptoms of bronchial asthma in children - functional and morphological consequences of the disease</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pediatric Allergy and Immunology
ISSN
0905-6157
e-ISSN
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Volume of the periodical
25
Issue of the periodical within the volume
6
Country of publishing house
DK - DENMARK
Number of pages
7
Pages from-to
593-599
UT code for WoS article
000344872400011
EID of the result in the Scopus database
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