IgE recognition patterns in peanut allergy are age dependent: perspectives of the EuroPrevall study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064211%3A_____%2F15%3A%230000456" target="_blank" >RIV/00064211:_____/15:#0000456 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11140/15:10326601

Result on the web

<a href="http://onlinelibrary.wiley.com/doi/10.1111/all.12574/abstract" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/all.12574/abstract</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/all.12574" target="_blank" >10.1111/all.12574</a>

Result language

angličtina

Original language name

IgE recognition patterns in peanut allergy are age dependent: perspectives of the EuroPrevall study

Original language description

Background: We tested the hypothesis that specific molecular sensitization patterns correlate with the clinical data/manifestation in a European peanut-allergic population characterized under a common protocol.Methods: Sixty-eight peanut-allergic subjects and 82 tolerant controls from 11 European countries were included. Allergy to peanut and lowest symptom-eliciting dose was established by double-blind placebo-controlled food challenge in all but anaphylactic subjects. Information of early or late (before or after 14 years of age) onset of peanut allergy was obtained from standardized questionnaires. IgE to peanut allergens rAra h 1-3, 6, 8-9, profilin and CCD was determined using ImmunoCAP.Results: Seventy-eight percent of peanut allergics were sensitized to peanut extract and 90% to at least one peanut component. rAra h 2 was the sole major allergen for the peanut-allergic population. Geographical differences were observed for rAra h 8 and rAra h 9, which were major allergens for central/western and southern Europeans, respectively. Sensitization to rAra h 1 and 2 was exclusively observed in early-onset peanut allergy. Peanut-tolerant subjects were frequently sensitized to rAra h 8 or 9 but not to storage proteins. Sensitization to Ara h 2 >= 1.0 kU(A)/l conferred a 97% probability for a systemic reaction (P = 0.0002). Logistic regression revealed a significant influence of peanut extract sensitization and region on the occurrence of systemic reactions (P = 0.0185 and P = 0.0436, respectively).Conclusion: Sensitization to Ara h 1, 2 and 3 is usually acquired in childhood. IgE to Ara h 2 >= 1.0 kU(A)/l is significantly associated with the development of systemic reactions to peanut.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FN - Epidemiology, infection diseases and clinical immunology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ALLERGY

ISSN

0105-4538

e-ISSN

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Volume of the periodical

70

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

17

Pages from-to

391-407

UT code for WoS article

000351654200007

EID of the result in the Scopus database

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