Ventilatory Efficiency Identifies Patients Prone to Hypoxemia During One-Lung Ventilation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F19%3A00070712" target="_blank" >RIV/00159816:_____/19:00070712 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/19:00110179 RIV/65269705:_____/19:00070712

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S105307701930093X?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S105307701930093X?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1053/j.jvca.2019.01.057" target="_blank" >10.1053/j.jvca.2019.01.057</a>

Result language

angličtina

Original language name

Ventilatory Efficiency Identifies Patients Prone to Hypoxemia During One-Lung Ventilation

Original language description

Objectives: One-lung ventilation (OLV) may be complicated by hypoxemia. Ventilatory efficiency, defined as the ratio of minute ventilation to carbon dioxide output (VE/VCO2), is increased with ventilation/perfusion mismatch and pulmonary artery hypertension, both of which may be associated with hypoxemia. Hence, the authors hypothesized increased VE/VCO2 will predict hypoxemia during OLV. Design: Prospective observational study. Setting: Single-center, university, tertiary care hospital. Participants: The study comprised 50 consecutive lung resection candidates. Interventions: All patients underwent cardiopulmonary exercise testing before surgery. Patients who required inspired oxygen fraction (FiO2) GREATER-THAN OR EQUAL TO0.7 to maintain arterial oxygen (O2) saturation &gt;90% after 30 minutes of OLV were considered to be hypoxemic. The Student t or Mann-Whitney U test were used for comparison of patients who became hypoxemic and those who did not. Multiple regression analysis adjusted for age, sex, and body mass index was used to evaluate which parameters were associated with the VE/VCO2 slope. Data are summarized as mean +- standard deviation. Measurements and Main Results: Twenty-four patients (48%) developed hypoxemia. There was no significant difference in age, sex, and body mass index between hypoxemic and nonhypoxemic patients. However, patients with hypoxemia had a significantly higher VE/VCO2 slope (30 +- 5 v 27 +- 4; p = 0.04) with exercise and lower partial pressure of oxygen/FiO2 (129 +- 92 v 168 +- 88; p = 0.01), higher mean positive end-expiratory pressure (6.6 +- 1.5 v 5.6 +- 0.9 cmH2O; p = 0.02), and lower mean pulse oximetry O2 saturation/FiO2 index (127 +- 20 v 174 +- 17; p &lt; 0.01) during OLV. Multiple regression showed VE/VCO2 to be independently associated with the mean pulse oximetry O2 saturation/FiO2 index (b = -0.28; F = 3.1; p = 0.05). Conclusions: An increased VE/VCO2 slope may predict hypoxemia development in patients who undergo OLV.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30223 - Anaesthesiology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of cardiothoracic and vascular anesthesia

ISSN

1053-0770

e-ISSN

—

Volume of the periodical

33

Issue of the periodical within the volume

7

Country of publishing house

US - UNITED STATES

Number of pages

7

Pages from-to

1956-1962

UT code for WoS article

000473249900028

EID of the result in the Scopus database

2-s2.0-85062476077