Causes of ventilatory inefficiency in lung resection candidates
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F25%3A00081682" target="_blank" >RIV/00159816:_____/25:00081682 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/25:00140639
Result on the web
<a href="https://publications.ersnet.org/content/erjor/11/2/00792-2024" target="_blank" >https://publications.ersnet.org/content/erjor/11/2/00792-2024</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1183/23120541.00792-2024" target="_blank" >10.1183/23120541.00792-2024</a>
Alternative languages
Result language
angličtina
Original language name
Causes of ventilatory inefficiency in lung resection candidates
Original language description
Introduction Ventilatory efficiency (V'E/V'CO2) has been shown to predict postoperative pulmonary complications (PPCs) in lung resection candidates. V'E/V'CO2 is determined by arterial partial pressure of carbon dioxide (PaCO2) and by dead space to tidal volume ratio (VD/VT). We hypothesised PaCO2 and VD /VT contribute equally to the increase in V'E/V'CO2 in lung resection patients. Methods Consecutive lung resection candidates from two prior prospective studies were included in this post hoc analysis. All subjects underwent preoperative spirometry, cardiopulmonary exercise testing and arterial blood gas analysis at rest and peak exercise. PPCs were prospectively assessed during the first 30 postoperative days, or hospital stay. A t-test, Mann-Whitney U-test and two-tailed Fisher's exact test were used to compare patients with and without PPCs. p-values <0.05 were considered statistically significant. Results Of 398 patients, PPC developed in 64 (16%). Patients with PPCs more frequently underwent lobectomy by open thoracotomy, had longer hospital and ICU length of stay and higher 30-and 90-day mortality. Moreover, patients with PPCs exhibited a higher V'E/V'CO2 ratio both at rest and peak exercise. Both ratios were independently associated with PPCs. At rest, the contribution of PaCO2 and VD/VT to the increase in V'E/V'CO2 ratio in patients with PPCs was 45% and 55%, respectively. At peak exercise, the contribution of PaCO2 and VD/VT to the increase in V'E/V'CO2 ratio was 16% and 84%, respectively. Conclusions VD/VT (V'/Q' mismatch and/or rapid shallow breathing pattern) is the dominant contributor to the increase in V'E/V'CO2 in lung resection candidates who develop PPCs.Methods: Consecutive lung resection candidates from two prior prospective studies were included inthis post-hoc analysis. All subjects underwent preoperative spirometry, cardiopulmonary exercisetesting and arterial blood gas analysis at rest and peak exercise. PPC were prospectively assessedduring the first 30 post-operative days, or hospital stay. Student t-test, Mann-Whitney U test and two-tailed Fisher exact test were used to compare patients with and without PPC. P values <0.05 wereconsidered statistically significant.Results: Of 398 patients, PPC developed in 64 (16%). Patients with PPC more frequently underwentlobectomy by open thoracotomy, had longer hospital and ICU length of stay and higher 30- and 90-day mortality. Moreover, patients with PPC exhibited higher VE/VCO2 ratio both at rest and peakexercise. Both ratios were independently associated with PPC. At rest, the contribution of PaCO2 andVD/VT to the increase in VE/VCO2 ratio in patients with PPC was 45% and 55%, respectively. At peakexercise, the contribution of PaCO2 and VD/VT to the increase in VE/VCO2 ratio was 16% and 84 %,respectively
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30203 - Respiratory systems
Result continuities
Project
<a href="/en/project/NU21-06-00086" target="_blank" >NU21-06-00086: High intensity respiratory muscle training as a pre-habilitation in lung surgery candidates</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ERJ Open Research
ISSN
2312-0541
e-ISSN
2312-0541
Volume of the periodical
11
Issue of the periodical within the volume
2
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
007922024
UT code for WoS article
001477535300001
EID of the result in the Scopus database
2-s2.0-105001867280