Focal control of non-invasive deep brain stimulation using multipolar temporal interference

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F25%3A00082300" target="_blank" >RIV/00159816:_____/25:00082300 - isvavai.cz</a>

Result on the web

<a href="https://link.springer.com/article/10.1186/s42234-025-00169-6" target="_blank" >https://link.springer.com/article/10.1186/s42234-025-00169-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s42234-025-00169-6" target="_blank" >10.1186/s42234-025-00169-6</a>

Result language

angličtina

Original language name

Focal control of non-invasive deep brain stimulation using multipolar temporal interference

Original language description

Temporal interference (TI) is a method of non-invasive brain stimulation using transcutaneous electrodes which allows the targeting and modulation of deeper brain structures, not normally associated with non-invasive simulation, while avoiding unwanted stimulation of shallower cortical structures. The properties of TI have been previously demonstrated, however, the problem of decoupling stimulation focality from stimulation intensity has not yet been well addressed. In this paper, we provide a possible novel solution, multipolar TI (mTI), which allows increased independent control over both the size of the stimulated region and the stimulation intensity. The mTI method uses multiple carrier frequencies to create multiple overlapping amplitude-modulated envelopes, rather than using one envelope as in standard TI. The study presents an explanation of the concept of mTI along with experimental data gathered from Rhesus macaques and mice. We improved the focality at depth in anesthetized mice and monkeys, and using the new focality in awake monkeys, evoked targeted activity at depth in the superior colliculus. The mTI method could be an interesting and potentially useful new tool alongside other forms of non-invasive brain stimulation. Teaser Multipolar Temporal Interference Stimulation can produce a more focal brain stimulation at depth compared to Temporal Interference.

Czech name

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Czech description

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Type

J_SC - Article in a specialist periodical, which is included in the SCOPUS database

CEP classification

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OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Bioelectronic medicine

ISSN

—

e-ISSN

2332-8886

Volume of the periodical

11

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

15

Pages from-to

nestránkováno

UT code for WoS article

001484107600001

EID of the result in the Scopus database

2-s2.0-105001282940