Circulating miR-378 and miR-451 in serum are potential biomarkers for renal cell carcinoma

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F12%3A10125073" target="_blank" >RIV/00179906:_____/12:10125073 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14740/12:00060118 RIV/00209805:_____/12:#0000342 RIV/00216208:11150/12:10125073
Result on the web
<a href="http://www.translational-medicine.com/content/10/1/55" target="_blank" >http://www.translational-medicine.com/content/10/1/55</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/1479-5876-10-55" target="_blank" >10.1186/1479-5876-10-55</a>

Result language
angličtina
Original language name
Circulating miR-378 and miR-451 in serum are potential biomarkers for renal cell carcinoma
Original language description
Background: There is no standard serum biomarker used for diagnosis or early detection of recurrence for renal cell carcinoma (RCC) patients. MicroRNAs (miRNAs) are abundant and highly stable in blood serum, and have been recently described as powerful circulating biomarkers in a wide range of solid cancers. Our aim was to identify miRNA signature that can distinguish the blood serum of RCC patients and matched healthy controls and validate identified miRNAs as potential biomarkers for RCC. Methods: Inthe screening phase of the study, blood serum of 15 RCC patients and 12 matched healthy controls were analyzed by use of the TaqMan Low-Density Arrays enabling parallel identification of expression levels of 667 miRNAs through qRT-PCR-based approach. Inthe validation phase, identified miRNAs were further evaluated on the independent group of 90 RCC patients and 35 matched healthy controls by use of individual qRT-PCR assays and statistically evaluated. Results: We identified 30 miRNAs d
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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