DNA released by leukemic cells contributes to the disruption of the bone marrow microenvironment

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10189109" target="_blank" >RIV/00216208:11110/13:10189109 - isvavai.cz</a>

Alternative codes found

RIV/68378050:_____/13:00422837 RIV/67985904:_____/13:00422837

Result on the web

<a href="http://dx.doi.org/10.1038/onc.2012.553" target="_blank" >http://dx.doi.org/10.1038/onc.2012.553</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/onc.2012.553" target="_blank" >10.1038/onc.2012.553</a>

Result language

angličtina

Original language name

DNA released by leukemic cells contributes to the disruption of the bone marrow microenvironment

Original language description

Reciprocal interactions between a tumor and its microenvironment control expansion of tumor cells. Here we show a specific type of interaction in which blasts of experimental leukemia destroy the bone marrow ( BM) structures and kill stromal cells. The in vitro experiments showed that the cytotoxic agent released by leukemic cells is the fragmented DNA derived from their genome and occurring in nucleosome-like complexes. This DNA entered nuclei of BM or other cells and induced H2A.X phosphorylation at serine 139, similar to double-strand break-inducing agents. There was a correlation between large amounts of acquired DNA and death of recipient cells. Moreover, the DNA integrated into chromosomal DNA of recipient cells. Primary human acute myeloid leukemia cells also released fragmented DNA that penetrated the nuclei of other cells both in vitro and in vivo. We suggest that DNA fragments released from leukemic and also perhaps other types of tumor cells can activate DNA repair mechanism

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Oncogene

ISSN

0950-9232

e-ISSN

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Volume of the periodical

32

Issue of the periodical within the volume

44

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

5201-5209

UT code for WoS article

000326497100003

EID of the result in the Scopus database

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