Adenylyl Cyclase Signaling in the Developing Chick Heart: The Deranging Effect of Antiarrhythmic Drugs

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10272173" target="_blank" >RIV/00216208:11110/14:10272173 - isvavai.cz</a>

Alternative codes found

RIV/67985823:_____/14:00438496 RIV/00216208:11310/14:10272173

Result on the web

<a href="http://dx.doi.org/10.1155/2014/463123" target="_blank" >http://dx.doi.org/10.1155/2014/463123</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2014/463123" target="_blank" >10.1155/2014/463123</a>

Result language

angličtina

Original language name

Adenylyl Cyclase Signaling in the Developing Chick Heart: The Deranging Effect of Antiarrhythmic Drugs

Original language description

The adenylyl cyclase (AC) signaling system plays a crucial role in the regulation of cardiac contractility. Here we analyzed the key components of myocardial AC signaling in the developing chick embryo and assessed the impact of selected beta-blocking agents on this system. Application of metoprolol and carvedilol, two commonly used beta-blockers, at embryonic day (ED) 8 significantly downregulated (by about 40%) expression levels of AC5, the dominant cardiac AC isoform, and the amount of Gs alpha protein at ED9. Activity of AC stimulated by forskolin was also significantly reduced under these conditions. Interestingly, when administered at ED4, these drugs did not produce such profound changes in the myocardial AC signaling system, except for markedlyincreased expression of Gi alpha protein. These data indicate that beta-blocking agents can strongly derange AC signaling during the first half of embryonic heart development.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

<a href="/en/project/GAP302%2F11%2F1308" target="_blank" >GAP302/11/1308: Epigenetic factors in myocardial morphogenesis</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

BioMed Research International

ISSN

2314-6133

e-ISSN

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Volume of the periodical

neuveden

Issue of the periodical within the volume

Jun

Country of publishing house

US - UNITED STATES

Number of pages

6

Pages from-to

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UT code for WoS article

000338534700001

EID of the result in the Scopus database

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