Low levels of circulating T-regulatory lymphocytes and short cervical length are associated with preterm labor

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10287133" target="_blank" >RIV/00216208:11110/14:10287133 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/14:10287133
Result on the web
<a href="http://dx.doi.org/10.1016/j.jri.2014.04.001" target="_blank" >http://dx.doi.org/10.1016/j.jri.2014.04.001</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jri.2014.04.001" target="_blank" >10.1016/j.jri.2014.04.001</a>

Result language
angličtina
Original language name
Low levels of circulating T-regulatory lymphocytes and short cervical length are associated with preterm labor
Original language description
Recent discoveries suggest that T-regulatory lymphocytes (Treg) might play an important role in the pathophysiology of preterm labor. The aim of this study was to assess the relationship among the levels of maternal circulating Treg cells, uterine cervical length, and the risk of preterm labor. Sixty women with regular contractions and/or cervical incompetence at 24-32 weeks' gestation were recruited into a prospective study. Each patient underwent transvaginal ultrasound examination of the cervical length, and regulatory T cells were quantified in peripheral blood samples by flow cytometry. Patients with cervical incompetence were prescribed vaginal progesterone until birth. Measurements of Treg levels and cervical length correlated with the timing oflabor. The risk of preterm labor happening within 48 h of testing was demonstrated to be almost 35 times higher (OR= 35.21, CI 13.3; 214, p < 0.001) in the group with simultaneously low Treg values (<0.031 x 10(9)/L) and a shortened uter
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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