Fecal zonulin is elevated in Crohn's disease and in cigarette smokers

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10366651" target="_blank" >RIV/00216208:11110/17:10366651 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/17:10366651

Result on the web

<a href="http://dx.doi.org/10.1016/j.plabm.2017.09.001" target="_blank" >http://dx.doi.org/10.1016/j.plabm.2017.09.001</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.plabm.2017.09.001" target="_blank" >10.1016/j.plabm.2017.09.001</a>

Result language

angličtina

Original language name

Fecal zonulin is elevated in Crohn's disease and in cigarette smokers

Original language description

Objectives: Human zonulin is a protein that increases permeability in the epithelial layer of the small intestine by reversibly modulating the intercellular tight junctions. There is not sufficient information available about zonulin&apos;s participation in inflammatory bowel diseases (IBD). The aim of this study was therefore to investigate fecal and serum zonulin in IBD patients and its relation to the disease localization, behavior and smoking status. Design and methods: Forty IBD patients and forty healthy persons were examined for fecal and serum zonulin concentrations by competitive ELISA (DRG International Inc). Values were correlated to IBD type, localization and behavior, and smoking. Results: Serum and fecal zonulin were significantly higher in patients with Crohn&apos;s disease compared to ulcerative colitis (p = 0.038 for fecal zonulin, and p = 0.041 for serum zonulin concentrations). No association of serum or fecal zonulin was found with respect to IBD localization and behavior. The only difference was found with respect to smoking. Both the IBD cohort and healthy smokers showed significantly higher fecal zonulin levels (median 203 ng/mL) compared to non-smokers (median 35.8 ng/mL), p &lt; 0.001. Conclusions: Fecal and serum zonulin levels are elevated in patients with active Crohn&apos;s disease but not with ulcerative colitis. High fecal zonulin levels in smokers irrespective of IBD point to the significant and undesirable up-regulation of gut permeability in cigarette smokers.

Czech name

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Czech description

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Type

J_SC - Article in a specialist periodical, which is included in the SCOPUS database

CEP classification

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OECD FORD branch

30219 - Gastroenterology and hepatology

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Practical Laboratory Medicine [online]

ISSN

2352-5517

e-ISSN

—

Volume of the periodical

9

Issue of the periodical within the volume

December

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

6

Pages from-to

39-44

UT code for WoS article

—

EID of the result in the Scopus database

2-s2.0-85030089146