Cellular and behavioural effects of a new steroidal inhibitor of the N-methyl-d-aspartate receptor 3?5?-pregnanolone glutamate

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F11%3A00003164" target="_blank" >RIV/00216208:11120/11:00003164 - isvavai.cz</a>

Alternative codes found

RIV/67985823:_____/11:00364480 RIV/61388963:_____/11:00364480 RIV/00023752:_____/11:00001189

Result on the web

<a href="http://dx.doi.org/10.1016/j.neuropharm.2011.02.018" target="_blank" >http://dx.doi.org/10.1016/j.neuropharm.2011.02.018</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.neuropharm.2011.02.018" target="_blank" >10.1016/j.neuropharm.2011.02.018</a>

Result language

angličtina

Original language name

Cellular and behavioural effects of a new steroidal inhibitor of the N-methyl-d-aspartate receptor 3?5?-pregnanolone glutamate

Original language description

Preclinical studies have demonstrated a considerable role for N-methyl-d-aspartate (NMDA) receptors in excitotoxicity and the concurrent neuroprotective effect of NMDA receptor antagonists. Because NMDA receptors are one of the most widespread receptorsin the central nervous system, application of their antagonist often leads to serious side effects ranging from motor impairment to induction of schizophrenic-like psychosis. Therefore, we have initiated development and testing of a novel synthetic NMDAreceptor antagonist derived from naturally occurring neurosteroids. 20-oxo-5?-pregnan-3?-yl-l-glutamyl-1-ester (3?5?P-Glu) is a novel synthetic steroidal inhibitor of the NMDA receptor. Our results show that 3?5?P-Glu preferentially inhibits tonically activated NMDA receptors, is able to cross the blood brain barrier, does not induce psychotomimetic symptoms (such as hyperlocomotion and sensorimotor gating deficit) and reduced an excitotoxic damage of brain tissue and subse

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuropharmacology

ISSN

0028-3908

e-ISSN

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Volume of the periodical

6

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

61-68

UT code for WoS article

000292408200007

EID of the result in the Scopus database

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