Cellular and behavioural effects of a new steroidal inhibitor of the N-methyl-D-aspartate receptor 3alfa5beta-pregnanolone glutamate

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F11%3A43891935" target="_blank" >RIV/60461373:22310/11:43891935 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.neuropharm.2011.02.018" target="_blank" >http://dx.doi.org/10.1016/j.neuropharm.2011.02.018</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.neuropharm.2011.02.018" target="_blank" >10.1016/j.neuropharm.2011.02.018</a>

Result language

angličtina

Original language name

Cellular and behavioural effects of a new steroidal inhibitor of the N-methyl-D-aspartate receptor 3alfa5beta-pregnanolone glutamate

Original language description

Preclin. studies have demonstrated a considerable role for N-methyl-D-aspartate (NMDA) receptors in excitotoxicity and the concurrent neuroprotective effect of NMDA receptor antagonists. Because NMDA receptors are one of the most widespread receptors inthe central nervous system, application of their antagonist often leads to serious side effects ranging from motor impairment to induction of schizophrenic-like psychosis. Therefore, we have initiated development and testing of a novel synthetic NMDA receptor antagonist derived from naturally occurring neurosteroids. 20-oxo-5beta-pregnan-3alfa-yl-L-glutamyl-1-ester (3alfa5betaP-Glu) is a novel synthetic steroidal inhibitor of the NMDA receptor. Our results show that 3alfa5betaP-Glu preferentially inhibits tonically activated NMDA receptors, is able to cross the blood brain barrier, does not induce psychotomimetic symptoms (such as hyperlocomotion and sensorimotor gating deficit) and reduced an excitotoxic damage of brain tissue and subs

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CC - Organic chemistry

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuropharmacology

ISSN

0028-3908

e-ISSN

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Volume of the periodical

61

Issue of the periodical within the volume

1

Country of publishing house

BE - BELGIUM

Number of pages

8

Pages from-to

61-68

UT code for WoS article

000292408200007

EID of the result in the Scopus database

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