Anxiogenic Effect of low-dose methamphetamine in the test of Elevated plus-maze

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F12%3A43907055" target="_blank" >RIV/00216208:11120/12:43907055 - isvavai.cz</a>

Result on the web

<a href="http://pmr.cuni.cz/file/5632/PMR2012A0022.pdf" target="_blank" >http://pmr.cuni.cz/file/5632/PMR2012A0022.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Anxiogenic Effect of low-dose methamphetamine in the test of Elevated plus-maze

Original language description

Methamphetamines (MA) are psychostimulant drugs that are known to change individuals' behavior. Psychostimulants could either evoke positive emotions (e.g. joy and happiness) or attenuate negative emotional states (e.g. anxiety and depression) in humans.In animal experiments, the test of elevated plus-maze (EPM) is widely used. This test is appropriate for evaluation of anxiolytic and anxiogenic drug effects, or for examination of specific subtypes of anxiety disorders. The aim of the present study wasto examine the effect of acute single dose of MA (1 mg/kg) on the behavior of laboratory rat in the EPM. The detailed ethologic analysis of behavior was performed using a modified protocol based on the study of Fernández Espejo (1997). Our results demonstrated that MA affects rat's behavior in the EPM in the majority of analyzed categories. The present protocol allowed us to determine positive anxiogenic effect of MA.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

<a href="/en/project/GAP303%2F10%2F0580" target="_blank" >GAP303/10/0580: What is the role of mesolimbic reward circuit in the long-term effect of prenatal methamphetamine exposure in rats?</a><br>

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Prague Medical Report

ISSN

1214-6994

e-ISSN

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Volume of the periodical

113

Issue of the periodical within the volume

3

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

8

Pages from-to

223-230

UT code for WoS article

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EID of the result in the Scopus database

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