Caspase-2 is involved in cell death induction by taxanes in breast cancer cells

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F13%3A43907485" target="_blank" >RIV/00216208:11120/13:43907485 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1186/1475-2867-13-42" target="_blank" >http://dx.doi.org/10.1186/1475-2867-13-42</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/1475-2867-13-42" target="_blank" >10.1186/1475-2867-13-42</a>

Result language

angličtina

Original language name

Caspase-2 is involved in cell death induction by taxanes in breast cancer cells

Original language description

We studied the role of caspase-2 in apoptosis induction by taxanes (paclitaxel, novel taxane SB-T-1216) in breast cancer cells using SK-BR-3 and MCF-7 cell lines. Both taxanes induced apoptosis in SK-BR-3 as well as MCF-7 cells. Caspase-2 activity in SK-BR-3 cells increased approximately 15-fold within 48 h after the application of both taxanes at the death-inducing concentration (100 nM). In MCF-7 cells, caspase-2 activity increased approximately 11-fold within 60 h after the application of taxanes (300 nM). Caspase-2 activation was confirmed by decreasing levels of procaspase-2, increasing levels of cleaved caspase-2 and the cleavage of caspase-2 substrate golgin-160. The inhibition of caspase-2 expression using siRNA increased the number of surviving cells more than 2-fold in MCF-7 cells, and at least 4-fold in SK-BR-3 cells, 96 h after the application of death-inducing concentration of taxanes. The inhibition of caspase-2 expression also resulted in decreased cleavage of initiator

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

<a href="/en/project/GA301%2F09%2F0362" target="_blank" >GA301/09/0362: Role of caspase-2 in apoptosis induction by taxanes in breast cancer cells</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cancer Cell International

ISSN

1475-2867

e-ISSN

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Volume of the periodical

13

Issue of the periodical within the volume

42

Country of publishing house

GB - UNITED KINGDOM

Number of pages

15

Pages from-to

1-15

UT code for WoS article

000320553000001

EID of the result in the Scopus database

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