Large contribution of human papillomavirus in vaginal neoplastic lesions: A worldwide study in 597 samples
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F14%3A43909050" target="_blank" >RIV/00216208:11120/14:43909050 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.ejca.2014.07.018" target="_blank" >http://dx.doi.org/10.1016/j.ejca.2014.07.018</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ejca.2014.07.018" target="_blank" >10.1016/j.ejca.2014.07.018</a>
Alternative languages
Result language
angličtina
Original language name
Large contribution of human papillomavirus in vaginal neoplastic lesions: A worldwide study in 597 samples
Original language description
Aim: This work describes the human papillomavirus (HPV) prevalence and the HPV type distribution in a large series of vaginal intraepithelial neoplasia (VAIN) grades 2/3 and vaginal cancer worldwide. Methods: We analysed 189 VAIN 2/3 and 408 invasive vaginal cancer cases collected from 31 countries from 1986 to 2011. After histopathological evaluation of sectioned formalin-fixed paraffin-embedded samples, HPV DNA detection and typing was performed using the SPF-10/DNA enzyme immunoassay (DEIA)/LiPA(25)system (version 1). A subset of 146 vaginal cancers was tested for p16(INK4a) expression, a cellular surrogate marker for HPV transformation. Prevalence ratios were estimated using multivariate Poisson regression with robust variance. Results: HPV DNA was detected in 74% (95% confidence interval (CI): 70-78%) of invasive cancers and in 96% (95% CI: 92-98%) of VAIN 2/3. Among cancers, the highest detection rates were observed in warty-basaloid subtype of squamous cell carcinomas, and in y
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
—
Result continuities
Project
—
Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Cancer
ISSN
0959-8049
e-ISSN
—
Volume of the periodical
50
Issue of the periodical within the volume
16
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
2846-2854
UT code for WoS article
000342701500012
EID of the result in the Scopus database
—