No Prognostic Impact of the WT1 Gene Single Nucleotide Polymorphism rs16754 in Pediatric Acute Myeloid Leukemia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F10%3A10209997" target="_blank" >RIV/00216208:11130/10:10209997 - isvavai.cz</a>
Alternative codes found
RIV/00064203:_____/10:10209997
Result on the web
<a href="http://dx.doi.org/10.1200/JCO.2010.29.3860" target="_blank" >http://dx.doi.org/10.1200/JCO.2010.29.3860</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1200/JCO.2010.29.3860" target="_blank" >10.1200/JCO.2010.29.3860</a>
Alternative languages
Result language
angličtina
Original language name
No Prognostic Impact of the WT1 Gene Single Nucleotide Polymorphism rs16754 in Pediatric Acute Myeloid Leukemia
Original language description
We have previously reported the poor prognostic impact of WT1 mutations in a large series of pediatric patients with AML, both in the entire group of patients as well as in those with CN-AML. Moreover, we identified a group with poor prognostics, characterized by the combined presence of a WT1 mutation and an FLT3-ITD. We also described the presence of SNP rs16754, which was distributed equally between WT1-mutated and WT1 wild-type samples, but we did not report its association with outcome. Furthermore, only a few samples were analyzed for WT1 mRNA expression in our series. Primed by the paper from Damm et al, we have now performed a full analysis of the characteristics and prognostic impact of WT1 SNP rs16754 and WT1 mRNA expression in pediatric AML.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Clinical Oncology
ISSN
0732-183X
e-ISSN
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Volume of the periodical
28
Issue of the periodical within the volume
28
Country of publishing house
US - UNITED STATES
Number of pages
4
Pages from-to
"E523"-"E526"
UT code for WoS article
000282272700014
EID of the result in the Scopus database
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