Positive contrast visualization of SPIO-labeled pancreatic islets using echo-dephased steady-state free precession

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F11%3A6943" target="_blank" >RIV/00216208:11130/11:6943 - isvavai.cz</a>

Alternative codes found

RIV/00023001:_____/11:00002433

Result on the web

<a href="http://www.ncbi.nlm.nih.gov/pubmed/20683599" target="_blank" >http://www.ncbi.nlm.nih.gov/pubmed/20683599</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Positive contrast visualization of SPIO-labeled pancreatic islets using echo-dephased steady-state free precession

Original language description

Objective MRI has recently been introduced as a promising method of monitoring the transplanted pancreatic islets labelled with superparamagnetic iron oxide (SPIO). However, the traditional T-2*-weighted approach frequently yields ambiguous results because of the negative contrast of the SPIO particles on the background of other body components. This obstacle could be overcome with the use of a novel method known as echo-dephased steady state free precession (SSFP), generating positive contrast in the presence of paramagnetic material. Methods In phantoms, we achieved exact localisation and clear positive contrast visualisation of human SPIO labelled islets. Using the proposed method we demonstrated the ability to detect even a single pancreatic isletagainst a homogeneous background. Results In vivo experiments in rats confirmed reliable and accurate localisation of transplanted SPIO labelled islets. Conclusion The echo-dephased SSFP technique could successfully visualise SPIO-labelle

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

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Continuities

R - Projekt Ramcoveho programu EK

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Radiology

ISSN

0938-7994

e-ISSN

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Volume of the periodical

21

Issue of the periodical within the volume

1

Country of publishing house

DE - GERMANY

Number of pages

7

Pages from-to

214-220

UT code for WoS article

000284899700029

EID of the result in the Scopus database

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